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The behavioral \u2018priming\u2019 effect of L\u2010DOPA is prevented if L\u2010DOPA is preceded by the NMDA\u2010receptor antagonist MK\u2010801. In the present study, the question is addressed whether blockade of the increased behavioral responsiveness with MK\u2010801 also prevents the observed changes in striatal neuropeptide mRNA levels. After a challenge with SKF\u201038393 (3 mg\/kg, s.c.), the striatal levels of preprodynorphin, preprotachykinin, and preproenkephalin mRNA were compared between unilaterally dopamine\u2010depleted rats that were either primed with a single administration of L\u2010DOPA (50 mg\/kg, i.p.) or with L\u2010DOPA preceded by MK\u2010801 (0.1 mg\/kg, i.p.). Priming with L\u2010DOPA enhanced the increase in dynorphin mRNA levels in the dorsolateral part of the dopamine\u2010depleted striatum that occurred after SKF\u201038393. On the other hand, it had no significant effect on substance P or enkephalin mRNA levels. MK\u2010801 prior to L\u2010DOPA prevented the increased responsiveness of dynorphin regulation. However, it induced a decreased response to dopamine D1\u2010receptor stimulation in the substance P mRNA levels in dorsal regions of the dopamine\u2010depleted striatum. The levels of enkephalin mRNA after challenge with SKF\u201038393 were not affected by the MK\u2010801 administration. These results demonstrate that the increased behavioral responsiveness to the D1\u2010receptor agonist SKF\u201038393 after priming with L\u2010DOPA is primarily related to the upregulation of dynorphin mRNA levels in the dopamine\u2010depleted striatum. Synapse 43:1\u201311, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.1113","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:19:04Z","timestamp":1030292344000},"page":"1-11","source":"Crossref","is-referenced-by-count":17,"title":["MK\u2010801 alters the effects of priming with L\u2010DOPA on dopamine D1 receptor\u2010induced changes in neuropeptide mRNA levels in the rat striatal output neurons"],"prefix":"10.1002","volume":"43","author":[{"given":"Serge V.","family":"Van De Witte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik 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