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Recent work showing increased motivational responsivity to amphetamine suggests that olfactory bulbectomy could also be a useful animal model of dual diagnosis disorders. To further investigate this possibility, we studied locomotor activity in olfactory bulbectomized rats 14 days postsurgery in response to novelty and upon acute and repeated injections of cocaine (15\/mg\/kg) or saline. Consistent with prior studies, lesioned animals showed greater locomotor activity in response to a novel environment and significantly heightened locomotor activation upon initial cocaine exposure. Over 7 days of repeated cocaine injections, lesioned animals also showed a presensitized pattern of activity, with a loss of incremental increases in locomotion observed in control animals. Daily saline injections produced no group differences in pre\u2010 or postinjection activity, while cocaine\u2010treated bulbectomized rats demonstrated a decline in their daily preinjection activity. These results suggest that neural alterations caused by olfactory bulbectomy produce altered behavioral response patterns to repeated doses of cocaine, and support the study of olfactory bulbectomy as a useful neurobehavioral model for understanding substance use disorder comorbidity in mental illness. Synapse 52:167\u2013175, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20017","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T19:32:47Z","timestamp":1080243167000},"page":"167-175","source":"Crossref","is-referenced-by-count":18,"title":["Locomotor sensitization to cocaine in rats with olfactory bulbectomy"],"prefix":"10.1002","volume":"52","author":[{"given":"R. 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