{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:46:23Z","timestamp":1789451183653,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,9,27]],"date-time":"2004-09-27T00:00:00Z","timestamp":1096243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Birth complications involving fetal hypoxia and stress at adulthood, which are risk factors for schizophrenia, can produce alterations in subcortical dopamine (DA) function in rat models. As adults, rats born either by cesarean section (C\u2010section) or by C\u2010section with added global anoxia show increased stress\u2010induced DA release from nucleus accumbens and increased amphetamine\u2010induced locomotion, compared to vaginally born controls. Moreover, stress at adulthood interacts with these birth insults to modulate DA receptor and transporter levels. Glutamatergic transmission at the level of the nucleus accumbens, prefrontal cortex, and hippocampus are known to modulate subcortical DA activity. Thus, altered excitatory amino acid (EAA) function might contribute to the dopaminergic changes observed in rats after birth insult and\/or stress at adulthood. To test this possibility, rats born vaginally, by C\u2010section, or by C\u2010section with 15 min of anoxia, were either repeatedly stressed (15 min of tail pinch daily for 5 days) at adulthood or received no stress, and levels of EAA receptor binding were measured by ligand autoradiography in limbic brain regions. As adults, rats born by C\u2010section showed increases in AMPA receptor binding in nucleus accumbens shell, NMDA receptor binding in cingulate cortex, and kainate receptor binding in the hippocampal CA1 region. Anoxic rats showed increases in CA1 kainate receptor and anterior olfactory NMDA receptor binding. Stress at adulthood increased AMPA receptor binding in several regions of prefrontal cortex and reduced NMDA receptor binding in infralimbic cortex and dentate gyrus, across all birth groups. Two instances of interactions between birth insult and stress at adulthood were observed. Stress reduced cingulate cortex NMDA receptor binding and increased olfactory tubercle kainate receptor binding only in C\u2010sectioned animals, but not in controls. The possibility that the observed EAA receptor changes contribute to dopaminergic dysfunction in these animal models is discussed, in light of known glutamate\u2010DA interactions. Synapse 54:138\u2013146, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20073","type":"journal-article","created":{"date-parts":[[2004,9,27]],"date-time":"2004-09-27T13:02:06Z","timestamp":1096290126000},"page":"138-146","source":"Crossref","is-referenced-by-count":19,"title":["Effects of birth insult and stress at adulthood on excitatory amino acid receptors in adult rat brain"],"prefix":"10.1002","volume":"54","author":[{"given":"Bassem F.","family":"El\u2010Khodor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit K.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Boksa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-01-00019.1996"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00435-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00092.2002"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1065"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s002219900305","article-title":"Interactive effects of anoxia and general anesthesia during birth on the degree of CNS and systemic hypoxia produced in neonatal rats","volume":"131","author":"Berger N","year":"2000","journal-title":"Exp Brain Res"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91041-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00012-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7896"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91392-6"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00543-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1523\/JNEUROSCI.20-14-05538.2000","article-title":"Perinatal distress leads to lateralized medial prefrontal cortical dopamine hypofunction in adult rats","volume":"20","author":"Brake WG","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2569"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-02-00653.1999"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245576"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.7.1080"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579402003139"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.237"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/2185"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a26.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00616-5"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91557-W"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91639-V"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6437"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00194-8"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00119-9"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00228-7"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200202110-00006"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00029-1"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04915.2001"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00183.2001"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12917"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.7.1141"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1316.075"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-07-02492.1997"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00049-1"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1984.tb09982.x"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1395198"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.168.1.49"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01152-6"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/0002-9378(82)90783-9","article-title":"Fetal and maternal plasma catecholamine levels at elective cesarean section under general or epidural anesthesia versus vaginal delivery","volume":"14","author":"Irestedt L","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63020785.x"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66041448.x"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(91)90007-U"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197708000-00007"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988119901300405"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00213-8"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00652-8"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00034-X"},{"key":"e_1_2_1_50_1","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1523\/JNEUROSCI.12-09-03609.1992","article-title":"Partial dopamine depletion of the prefrontal cortex leads to enhanced mesolimbic dopamine release elicited by repeated exposure to naturally reinforcing stimuli","volume":"12","author":"Mitchell JB","year":"1992","journal-title":"J Neurosci"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00290-2"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10106"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199711)27:3<168::AID-SYN2>3.0.CO;2-B"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.162.2.161"},{"key":"e_1_2_1_55_1","first-page":"607","article-title":"Fetal catecholamine release in response to labor and delivery","volume":"60","author":"Padbury JF","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5400.401"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00021-0"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00017-5"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(99)00057-4"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90021-3"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71041443.x"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1063(2000)10:4<411::AID-HIPO7>3.0.CO;2-A"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.42.082701.160735"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7201"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00292-5"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1991.tb00036.x"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(200008)37:2<159::AID-SYN9>3.0.CO;2-N"},{"key":"e_1_2_1_68_1","first-page":"1145","article-title":"alpha\u2010Amino\u20103\u2010hydroxy\u20105\u2010methylisoxazole\u20104\u2010propionate\/kainate receptor antagonists in the nucleus accumbens and ventral pallidum decrease the hypermotility response to psychostimulant drugs","volume":"260","author":"Willins DL","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1300.015"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1139\/y93-061"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000575"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(02)00347-0"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.20073","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.20073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T03:07:50Z","timestamp":1700190470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.20073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,28]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1002\/syn.20073"],"URL":"https:\/\/doi.org\/10.1002\/syn.20073","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,28]]}}}