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Each individual topography of behaviour within the natural repertoire was assessed over the extended course of initial exploration of and subsequent habituation to the environment, and following challenge with a series of D<jats:sub>1<\/jats:sub>\u2010like agonists. Over initial exploration, D<jats:sub>5<\/jats:sub>\u2010null mice evidenced a modest reduction in locomotion and a modest increase in sifting. Subsequent habituation revealed additional phenotypic effects, primarily overall reduction in grooming and delayed habituation of rearing. Among D<jats:sub>1<\/jats:sub>\u2010like agonists, A 68930 stimulates both adenylyl cyclase and a putative D<jats:sub>1<\/jats:sub>\u2010like receptor coupled to stimulation of phospholipase C\u2010mediated phosphoinositide hydrolysis; conversely, SK&amp;F 83959 stimulates phosphoinositide hydrolysis but not adenylyl cyclase while SK&amp;F 83822 stimulates adenylyl cyclase but not phosphoinositide hydrolysis. Though programmed grooming syntax and episodic seizure activity induced by A 68930 and SK&amp;F 83822 were unaltered, grooming induced by SK&amp;F 83959 was reduced in D<jats:sub>5<\/jats:sub> mutants. Stereotyped, ponderous locomotion induced by the D<jats:sub>2<\/jats:sub>\u2010like agonist RU 24213 was enhanced in D<jats:sub>5<\/jats:sub> mutants. Phenotypic and pharmacological characterisation of congenic D<jats:sub>5<\/jats:sub>\u2010null mice at an ethological level identifies novel functional roles for the D<jats:sub>5<\/jats:sub> receptor in mediating discrete topographies of behaviour relating to exploration, sequential motor coordination, and how these processes change over the course of interaction with and habituation to the environment. Additionally, they indicate the involvement of phosphoinositide hydrolysis and D<jats:sub>5<\/jats:sub>:D<jats:sub>2<\/jats:sub>\u2010like interactions in regulating these processes. Synapse 55:201\u2013211, 2005. 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