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Adult male Sprague\u2010Dawley rats received bilateral intrastriatal 0.8\u2010\u03bcl infusions of the NK1R receptor antagonist LY 306,740 (0, 27, or 54 nmol\/side) followed by intrastriatal infusions of SKF 82958 (0 or 24 nmol\/side) into the dorsal striatum. Following each infusion, rats were placed into automated activity monitors for the quantification of horizontal activity, total distance traveled, movement bouts, and stereotypy counts. As expected, SKF 82958 increased motor activity on all behavioral measures. More importantly, whereas 27 nmol was without effect, prior infusion of 54 nmol LY 306,740 significantly reduced most aspects of behavior. The results of this study suggest that functional NK1Rs within the striatum play a permissive role in the motor behaviors induced by D1R stimulation. 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