{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:50:04Z","timestamp":1778712604709,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2005,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transient global anoxia after Cesarean birth in rats may produce alterations in the subcortical DA function and related behaviors. The reports only tested the behavioral changes induced by a general DA agonist, such as amphetamine or apomorphine, in adult rats. Here we investigated the role of perinatal anoxia on the locomotion induced by a specific dopamine (DA) agonist and its relation to the DA D1\u2010like and D2\u2010like receptors, measured by autoradiography at two different ages, prepubertal (35 days old, P35) and postpubertal (60 days old, P60). Cesarean birth with or without (C\u2010only) an additional period of 10 min of the anoxia was done in Sprague\u2010Dawley rats, and the effects of the DA D1\u2010like and D2\u2010like agonist and their receptors were studied at P35 and P60. In addition, a third group of animals born vaginally served as the control. The quantitative autoradiography study of the DA D1\u2010like and D2\u2010like receptors revealed an enhancement of the DA D1\u2010like receptor levels in the nucleus accumbens (NAcc) and dorsolateral part of the caudate\u2013putamen in the prepubertal C\u2010only animals. The postpubertal C\u2010only rats showed a decrease in the levels of DA D2\u2010like receptors in the NAcc. However, quinpirole, a DA D2 agonist (0.125 and 0.25 mg\/kg, s.c.), induced a dose\u2010dependent increase of the locomotor activity in the animals born by Cesarean with anoxia at birth at both ages. Our results suggest that Cesarean with or without anoxia at birth may mediate differently the neurodevelopmental aspects of the dopaminergic system before and after puberty. Synapse 58:236\u2013242, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20203","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T18:48:23Z","timestamp":1128365303000},"page":"236-242","source":"Crossref","is-referenced-by-count":10,"title":["Cesarean plus anoxia at birth induces hyperresponsiveness to locomotor activity by dopamine D2 agonist"],"prefix":"10.1002","volume":"58","author":[{"given":"Ismael","family":"Ju\u00e1rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fidel","family":"De La 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