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DA D1 or D3 receptor homozygous knockout (D1\u2212\/\u2212 or D3\u2212\/\u2212) mice offer the opportunity to test the roles of these specific receptors in regulating MOP\u2010r gene expression in response to cocaine. In the present studies, we found an increase in basal MOP\u2010r mRNA levels in the FC of both D1\u2212\/\u2212 and D3\u2212\/\u2212 mice compared to wild type controls, with no change in the nucleus accumbens (NAc) core or caudate\u2013putamen (CPu). Acute \u201cbinge\u201d cocaine (3 \u00d7 15 mg\/kg for 2.5 h) returned FC MOP\u2010r mRNA levels in D1\u2212\/\u2212 or D3\u2212\/\u2212 mice to those in wild type controls. In the NAc core, the MOP\u2010r mRNA levels after acute \u201cbinge\u201d cocaine were decreased in D1\u2212\/\u2212 mice while increased in D3\u2212\/\u2212 mice. In the CPu, however, the MOP\u2010r mRNA levels after acute \u201cbinge\u201d cocaine were increased in D1\u2212\/\u2212 mice while decreased in D3\u2212\/\u2212 mice. We also found a decrease in basal orexin mRNA levels in the lateral hypothalamus of the D3\u2212\/\u2212 mice, which was unaltered by acute \u201cbinge\u201d cocaine. Together, our findings suggest that: (1) both D1 and D3 receptors are involved in FC MOP\u2010r gene regulation; and (2) D1 and D3 receptors play opposite roles in the effects of cocaine on MOP\u2010r gene regulation differentially in the NAc core or CPu. Synapse 61:50\u201359, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20340","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T18:17:35Z","timestamp":1161886655000},"page":"50-59","source":"Crossref","is-referenced-by-count":7,"title":["Effects of acute \u201cbinge\u201d cocaine on mRNA levels of \u03bc opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout 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