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We studied the levodopa action on two extracellular DA pools: one was analyzed by microdialysis (often considered as indicative of volume transmission) and the other by in vivo amperometry during nigrostriatal cell stimulation (more indicative of neurotransmission). Levodopa administration induced a moderate (\u2191200%) and tardy (began at 60 min) increase in the DA\u2010pool measured by microdialysis, an effect that increased (\u2191500%) and accelerated (began at 10 min) after DA\u2010cell degeneration. Levodopa action on the DA\u2010pool measured by amperometry was very fast (10 min) and prominent (\u2191600%) in normal rats. The DA\u2010denervated striatum showed a fast exhaustion during cell stimulation, which prevented further study of the levodopa effect on the DA amperometry\u2010pool under this condition. This study suggests a different kinetic for levodopa action on the volume transmitter and neurotransmitter DA\u2010pool, showing marked changes in levodopa action in the denervated striatum. Synapse 61:61\u201371, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20342","type":"journal-article","created":{"date-parts":[[2006,11,21]],"date-time":"2006-11-21T18:23:05Z","timestamp":1164133385000},"page":"61-71","source":"Crossref","is-referenced-by-count":29,"title":["Different levodopa actions on the extracellular dopamine pools in the rat 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