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When TGF\u03b1 is reduced in Waved\u20101 (Wa\u20101) mutant mice, brain anatomy, biogenic amines, stress response, and behavior are normal prior to, but altered following puberty. As an initial screen for possible alterations in nigrostriatal and mesolimbic dopamine (DA) systems, we tested adult Wa\u20101 mutant mice in an open field, following acute injection with cocaine (15 mg\/kg). Wa\u20101 mice exhibited significantly greater ambulatory distance, number of ambulatory episodes, and cocaine\u2010induced motor stereotypies than do controls. These data indicate that adult Wa\u20101 mice are hypersensitive to the locomotor effects of cocaine and provide a new potential link between neurodevelopmental processes and adult psychostimulant responsiveness. 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