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In vivo electrophysiology in the anesthetized rat was used to examine mPFC and BLA activity simultaneously in response to FG\u20107142, a benzodiazepine receptor partial inverse agonist that mimics various stress responses, in an attempt to model the effects of stressors on corticolimbic functional connectivity. Extracellular unit and local field potential (LFP) recordings, using multielectrode arrays positioned in mPFC and BLA, were conducted under basal conditions and in response to systemic FG\u20107142 administration. This drug increased mPFC and BLA unit firing at the lowest dose tested, whereas higher doses of FG\u20107142 decreased various burst firing parameters in both regions. Moreover, LFP power was attenuated at lower (&lt;1 Hz) and potentiated at higher frequencies in mPFC (1\u201312 Hz) and BLA (4\u20138 Hz). Interestingly, FG\u20107142 diminished synchronized unit firing, both within and between mPFC and BLA. Finally, FG\u20107142 decreased LFP synchronization between these regions. In a separate group of animals, pretreatment with the selective benzodiazepine receptor antagonist flumazenil blocked the changes in burst firing, LFP power and synchronized activity induced by FG\u20107142, confirming direct benzodiazepine receptor\u2010mediated effects. These results indicate that FG\u20107142 disrupts corticolimbic network interactions via benzodiazepine receptor partial inverse agonism. Perturbation of mPFC\u2010BLA functional connectivity induced by FG\u20107142 may provide a useful model of corticolimbic dysfunction induced by stressors. Synapse 61:646\u2013663, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20414","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T18:53:03Z","timestamp":1179168783000},"page":"646-663","source":"Crossref","is-referenced-by-count":20,"title":["Systemic administration of the benzodiazepine receptor partial inverse agonist FG\u20107142 disrupts corticolimbic network interactions"],"prefix":"10.1002","volume":"61","author":[{"given":"Carl W.","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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