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This study was conducted to further investigate potential persistent psychomotor deficits secondary to METH abuse, and their relationship to brain DAT availability, as measured using quantitative PET methods with [<jats:sup>11<\/jats:sup>C]WIN 35428. <jats:italic>Methods:<\/jats:italic> Twenty\u2010two abstinent METH users and 17 healthy non\u2010METH using controls underwent psychometric testing to test the hypothesis that METH users would demonstrate selective deficits in neuropsychiatric domains known to involve DA neurons (e.g., working memory, executive function, motor function). A subset of subjects also underwent PET scanning with [<jats:sup>11<\/jats:sup>C]WIN 35428. <jats:italic>Results:<\/jats:italic> METH users were found to have modest deficits in short\u2010term memory, executive function, and manual dexterity. Exploratory correlational analyses revealed that deficits in memory, but not those in executive or motor function, were associated with decreases in striatal DAT BP. <jats:italic>Conclusions:<\/jats:italic> These results suggest a possible relationship between DAT BP and memory deficits in abstinent METH users, and lend support to the notion that METH produces lasting effects on central DA neurons in humans. As METH can also produce toxic effects on serotonin (5\u2010HT) neurons, further study is needed to address the potential role of brain 5\u2010HT depletion in cognitive deficits in abstinent METH users. Synapse 62:91\u2013100, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20471","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T19:16:19Z","timestamp":1194549379000},"page":"91-100","source":"Crossref","is-referenced-by-count":175,"title":["Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users"],"prefix":"10.1002","volume":"62","author":[{"given":"Una D.","family":"McCann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubyna","family":"Abbey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Brasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohab","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Dannals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean F.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Ricaurte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(69)90057-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00221309.1948.9918159"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1532"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688638508401274"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199710)27:2<153::AID-SYN6>3.0.CO;2-D"},{"key":"e_1_2_1_7_1","volume-title":"Epidemiologic trends in drug abuse, advance report and highlights\/executive summary","author":"CEWG (NIDA Community Epidemiology Work Group)","year":"2005"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.004"},{"key":"e_1_2_1_9_1","first-page":"269","volume-title":"Amphetamine and its analogs: Neuropsychopharmacology, toxicology and abuse","author":"Gibb JW","year":"1994"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.6.1578"},{"key":"e_1_2_1_11_1","volume-title":"Brain and intelligence. 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