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To further characterize the influence of pallidal A<jats:sub>2A<\/jats:sub> receptor blockade on the motor stimulant effects elicited by dopamine receptor activation, hemiparkinsonian rats were infused with the water\u2010soluble A<jats:sub>2A<\/jats:sub> antagonist SCH BT2 in the GP, alone or in combination with systemic administration of either SKF 38393 or quinpirole, to stimulate dopamine D<jats:sub>1<\/jats:sub> or D<jats:sub>2<\/jats:sub> receptors, respectively. SCH BT2 alone (5 \u03bcg\/1 \u03bcl) neither altered motor behavior nor produced postural asymmetry. In contrast, the contralateral rotations elicited by SKF 38393 (1.5 mg\/kg) as well as quinpirole (0.05 mg\/kg) were potentiated by the concomitant intrapallidal infusion of SCH BT2. The results of this study demonstrate that blockade of pallidal A<jats:sub>2A<\/jats:sub> receptors exerts a facilitatory influence on the motor effects produced by the selective stimulation of either D<jats:sub>1<\/jats:sub> or D<jats:sub>2<\/jats:sub> dopamine receptors in hemiparkinsonian rats and suggest an involvement of GP in the antiparkinsonian activity of A<jats:sub>2A<\/jats:sub> receptor antagonists. 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