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Although no effective medication currently exists for its treatment, racemic \u03b3 vinyl\u2010GABA (R,S\u2010GVG, vigabatrin) shows enormous potential as it blocks both the neurochemical and behavioral effects of a variety of drugs, including METH, heroin, morphine, ethanol, nicotine, and cocaine. Using the reinstatement of a conditioned place preference (CPP) as an animal model of relapse, the present study specifically investigated the ability of an acute dose of R,S\u2010GVG to block METH\u2010triggered reinstatement of a METH\u2010induced CPP. Animals acquired a METH CPP following a 20\u2010day\u2010period of conditioning, in which they received 10 pairings of alternating METH and saline injections. During conditioning, rats were assigned to one of four METH dosage groups: 1.0, 2.5, 5.0, or 10.0 mg\/kg (i.p.,<jats:italic>n<\/jats:italic>= 8\/group). Animals in all dosage groups demonstrated a robust and consistent CPP. This CPP was subsequently extinguished in each dosage group with repeated saline administration. Upon extinction, all groups reinstated following an acute METH challenge. On the following day, an acute dose of R,S\u2010GVG (300 mg\/kg, i.p.) was administered 2.5 h prior to an identical METH challenge. R,S\u2010GVG blocked METH\u2010triggered reinstatement in all four groups. Given that drug re\u2010exposure may potentiate relapse to drug\u2010seeking behavior, the ability of R,S\u2010GVG to block METH\u2010triggered reinstatement offers further support for its use in the successful management of METH dependence. 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