{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:02:42Z","timestamp":1761393762499,"version":"3.37.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,28]],"date-time":"2009-01-28T00:00:00Z","timestamp":1233100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methamphetamine (mAMPH) is a highly addictive psychostimulant drug that injures monoaminergic neurons and results in behavioral impairments in humans and animals. Although evidence exists for changes in cortical volume, metabolism, and blood oxygenation levels in human mAMPH abusers, animal models have instead emphasized this drug's long\u2010lasting influence on ascending monoaminergic (dopamine, serotonin) projections. The aim of this study was to investigate cortical and subcortical function in rats long after administration of a single\u2010day mAMPH regimen known to damage monoaminergic systems, at a time point when behavioral impairments are still evident. Rats were given either saline or a neurotoxic (4 \u00d7 4 mg\/kg, sc) mAMPH regimen. Five weeks later, they were given pharmacological treatments that stimulate cortical gene expression: either the dopaminergic agonist apomorphine (3 mg\/kg, sc) or the muscarinic acetylcholine agonist pilocarpine (25 mg\/kg, ip). Cortical and subcortical immediate early gene (IEG) responses were measured by immunocytochemical analysis of Fos or JunB, protein products of the IEGs, c\u2010<jats:italic>fos<\/jats:italic>and<jats:italic>junB<\/jats:italic>. Compared with saline\u2010pretreated controls, mAMPH\u2010pretreated animals had about 50\u201370% fewer Fos\u2010 and JunB\u2010immunoreactive cells in anterior cingulate, infralimbic, orbital, somatosensory, and rhinal cortices as well as caudate\u2010putamen and nucleus accumbens, 90 min after apomorphine challenge. By contrast, mAMPH\u2010pretreated rats had no reductions in the numbers of Fos or JunB\u2010positive cells following pilocarpine challenge. This study demonstrates the profound and enduring effects of mAMPH administration on dopamine\u2010stimulated cortical function in animals. Synapse 63:403\u2013412, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20617","type":"journal-article","created":{"date-parts":[[2009,1,28]],"date-time":"2009-01-28T16:58:08Z","timestamp":1233161888000},"page":"403-412","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term changes in dopamine\u2010stimulated gene expression after single\u2010day methamphetamine exposure"],"prefix":"10.1002","volume":"63","author":[{"given":"Annabelle M.","family":"Belcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"O'dell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(09)90007-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890090405"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(00)00136-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300771"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0022-3565(25)39533-9","article-title":"Activation of transcription factor genes in striatum by cocaine: Role of both serotonin and dopamine systems","volume":"267","author":"Bhat RV","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02599-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/S0022-3565(25)38650-7","article-title":"Further studies of the role of hyperthermia in methamphetamine neurotoxicity","volume":"268","author":"Bowyer JF","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890110404"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-17-07653.1999"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00885.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0022-3565(24)38769-5","article-title":"Long\u2010term changes in basal ganglia function after a neurotoxic regimen of methamphetamine","volume":"296","author":"Chapman DE","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb11358.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90717-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00184-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90024-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1923"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199812)30:4<433::AID-SYN10>3.0.CO;2-O"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199603)22:3<217::AID-SYN3>3.0.CO;2-F"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.26975"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.47.120505.105140"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(97)00094-9"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0741363.x"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02439-2"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04919.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00029-9"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/45790"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300699"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005699"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.039"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3597-04.2004"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01780.x"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90287-9"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-20-08417.1998"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0022-3565(25)22434-X","article-title":"Environment\u2010, drug\u2010 and stress\u2010induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL\/6J mouse","volume":"270","author":"Miller DB","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(02)00051-8"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1523\/JNEUROSCI.13-02-00423.1993","article-title":"Coordinate expression of c\u2010fos and jun B is induced in the rat striatum by cocaine","volume":"13","author":"Moratalla R","year":"1993","journal-title":"J Neurosci"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.14.030191.002225"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(200007)37:1<32::AID-SYN4>3.0.CO;2-X"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91461-9"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00097-X"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00334-7"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01442-7"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209532200"},{"issue":"2","key":"e_1_2_1_45_1","first-page":"S62","article-title":"Metabolic mapping of the toxic effects of methamphetamine in the rat brain","volume":"11","author":"Pontieri FE","year":"1991","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03464.x"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90952-X"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10210"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-03-00900.1993"},{"key":"e_1_2_1_50_1","first-page":"60","article-title":"Brain monoamines and behavior","volume":"11","author":"Seiden LS","year":"1975","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.1.90"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v21n01_06"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05449.2000"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890170310"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91304-6"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.04.003"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05688.x"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0713-04.2004"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.12.2015"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.383"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.377"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.02.025"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.02.022"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2007.01.046"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1369.001"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.20617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.20617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T08:14:48Z","timestamp":1738916088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.20617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,28]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1002\/syn.20617"],"URL":"https:\/\/doi.org\/10.1002\/syn.20617","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"type":"print","value":"0887-4476"},{"type":"electronic","value":"1098-2396"}],"subject":[],"published":{"date-parts":[[2009,1,28]]}}}