{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T20:10:10Z","timestamp":1739131810152,"version":"3.37.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T00:00:00Z","timestamp":1243555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The<jats:italic>Taiep<\/jats:italic>rat is a myelin mutant with a motor syndrome characterized by tremor, ataxia, immobility, epilepsy, and paralysis. The rat shows a hypomyelination followed by a progressive demyelination. During immobilities<jats:italic>taiep<\/jats:italic>rats show a REM\u2010like sleep pattern and a disorganized sleep\u2010wake pattern suggesting<jats:italic>taiep<\/jats:italic>rats as a model of narcolepsy\u2010cataplexy. Our study analyzed the role of postsynaptic serotonin receptors in the expression of gripping\u2010induced immobility episodes (IEs) in 8\u2010month\u2010old male<jats:italic>taiep<\/jats:italic>rats. The specific postsynaptic serotonin agonist \u00b11\u2010(2,5\u2010dimethoxy\u20104\u2010iodoamphetamine hydrochloride (\u00b1DOI) decreased the frequency of gripping\u2010induced IEs, but that was not the case with \u03b1\u2010methyl\u2010serotonin maleate (\u03b1\u2010methyl\u20105HT), a nonspecific postsynaptic agonist. Although the serotonin antagonists, ketanserine and metergoline, produced a biphasic effect, first a decrease followed by an increase with higher doses, similar effects were obtained with a mean duration of gripping\u2010induced IEs. These findings correlate with the pharmacological observations in narcoleptic dogs and humans in which serotonin\u2010reuptake inhibitors improve cataplexy, particularly in long\u2010term treatment that could change the serotonin receptor levels. Polysomnographic recordings showed an increase in the awakening time and a decrease in the slow wave and rapid eye movement sleep concomitant with a decrease in immobilities after use of \u00b1DOI, this being stronger with the highest dose. Taken together, our results show that postsynaptic serotonin receptors are involved in the modulation in gripping\u2010induced IEs caused by the changes in the organization of the sleep\u2010wake cycle in<jats:italic>taiep<\/jats:italic>rats. It is possible that specific agonists, without side effects, could be a useful treatment in human narcoleptic patients. Synapse 63:737\u2013744, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20655","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T19:10:24Z","timestamp":1243624224000},"page":"737-744","source":"Crossref","is-referenced-by-count":1,"title":["Serotonergic\u2010postsynaptic receptors modulate gripping\u2010induced immobility episodes in male<i>taiep<\/i>rats"],"prefix":"10.1002","volume":"63","author":[{"given":"Jos\u00e9 R.","family":"Eguibar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Ita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,29]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"34","article-title":"Narcolepsy","volume":"42","author":"Aldrich MS","year":"1992","journal-title":"Neurology"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.09.026"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90038-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21109"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1768-y"},{"first-page":"148","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Clark D","key":"e_1_2_1_7_1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-03-00743.1989"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81973-X"},{"key":"e_1_2_1_10_1","article-title":"Catecholaminergic uptake inhibitors decrease gripping\u2010induced immobility episodes in a mutant rat taiep","author":"Cort\u00e9s MC","year":"2000","journal-title":"Soc Neurosci"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20188"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.10.048"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970315)47:6<573::AID-JNR2>3.0.CO;2-A"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)00340-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90047-L"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511541674.015"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00439544"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01191684"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20305"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.08.007"},{"key":"e_1_2_1_21_1","unstructured":"GavitoB.2001.Efecto de la administraci\u00f3n cr\u00f3nica de inhibidores de recaptura de aminas biog\u00e9nicas sobre la inmovilidad inducida en la ratataiep. 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