{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:53:37Z","timestamp":1773057217431,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T00:00:00Z","timestamp":1256169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose<\/jats:bold>: The purpose of this study was to explore and discuss the effects of 660\u2010nm gallium\u2013aluminum\u2013arsenide low\u2010energy laser (GaAlAs LEL) irradiation on neural regeneration after acellular nerve allograft repair of the sciatic nerve gap in rats. <jats:bold>Methods<\/jats:bold>: Eight male and female Sprague\u2013Dawley rats were used as nerve donors, and 32 healthy Wistar rats were randomly divided into four groups: normal control group, acellular rat sciatic nerve (ARSN) group, laser group, and autograft group. Twelve weeks after surgery, nerve conduction velocity, restoration rate of tibialis anterior wet muscle weight, myelinated nerve number, and calcitonin gene\u2010related peptide (CGRP) protein and mRNA expression of the spinal cord and muscle at the injury site were quantified and statistically analyzed. <jats:bold>Results<\/jats:bold>: Compared with the ARSN group, laser therapy significantly increased nerve conduction velocity, restoration rate of tibialis anterior wet muscle weight, myelinated nerve number, and CGRP protein and mRNA expression of the L<jats:sub>4<\/jats:sub> spinal cord at the injury site. <jats:bold>Conclusions<\/jats:bold>: These findings demonstrate that 660\u2010nm GaAlAs LEL therapy upregulates CGRP protein and mRNA expression of the L<jats:sub>4<\/jats:sub> spinal cord at the injury site and increases the rate of regeneration and target reinnervation after acellular nerve allograft repair of the sciatic nerve gap in rats. Low\u2010energy laser irradiation may be a useful, noninvasive adjunct for promoting nerve regeneration in surgically induced defects repaired with ARSN. Synapse 64:152\u2013160, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20724","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T22:57:50Z","timestamp":1256252270000},"page":"152-160","source":"Crossref","is-referenced-by-count":21,"title":["Effects of 660\u2010nm gallium\u2013aluminum\u2013arsenide low\u2010energy laser on nerve regeneration after acellular nerve allograft in 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