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In this study, we examined whether the endogenous peroxisome proliferator\u2010activated receptor\u2010\u03b1 (PPAR\u2010\u03b1) agonist, oleoylethanolamide (OEA) protects against these MDMA\u2010induced deficits. Mice were pretreated twice a day with OEA (0, 5, and 25 mg\/kg) 30 min before an injection of MDMA (30 mg\/kg) or saline during four consecutive days. Twenty\u2010four hours after the last treatment, animals were trained in an active avoidance task for two consecutive weeks. After a 5\u2010day resting period, a recall session was performed. Mice treated with MDMA showed reduced learning and recall of the task when compared with saline\u2010treated controls. OEA at 5 mg\/kg ameliorated and at 25 mg\/kg worsened this deficit. Dopamine transporter (DAT)\u2010binding sites significantly decreased 4 days after the last MDMA administration and pretreatment with both doses of OEA prevented this effect. In immunohistochemical studies, coexpression of tyrosine\u2010hydroxylase and PPAR\u2010\u03b1 receptors was observed in the striatum and substantia nigra pars compacta of mice. These results suggest that OEA administration can modulate the cognitive deficits induced by MDMA in a DAT\u2010independent manner. Synapse 64:379\u2013389, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20733","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T15:55:56Z","timestamp":1261497356000},"page":"379-389","source":"Crossref","is-referenced-by-count":40,"title":["Effects of the endogenous PPAR\u2010\u03b1 agonist, oleoylethanolamide on MDMA\u2010induced cognitive deficits in mice"],"prefix":"10.1002","volume":"64","author":[{"given":"Ainhoa","family":"Plaza\u2010Zabala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Berrendero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco 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