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The purpose of this experiment was to determine if adrenal inactivation during and following MA exposure would attenuate the egocentric learning deficits in the Cincinnati water maze (CWM). In the first experiment, the effects of adrenalectomy (ADX) or sham surgery (SHAM) on MA\u2010induced neurotoxicity at 72 h were determined. SHAM\u2010MA animals showed typical patterns of hyperthermia, whereas ADX\u2010MA animals were normothermic. Both SHAM\u2010MA\u2010 and ADX\u2010MA\u2010treated animals showed increased neostriatal glial fibrillary acidic protein and decreased monoamines in the neostriatum, hippocampus, and entorhinal cortex. In the second experiment, SHAM\u2010MA\u2010 and ADX\u2010MA\u2010treated groups showed equivalently impaired CWM performance 2 weeks post\u2010treatment (increased latencies, errors, and start returns) compared to SHAM\u2010saline (SAL) and ADX\u2010SAL groups with no effects on novel object recognition, elevated zero maze, or acoustic startle\/prepulse inhibition. Post\u2010testing, monoamine levels remained decreased in both MA\u2010treated groups in all three brain regions, but were not as large as those observed at 72\u2010h post\u2010treatment. The data demonstrate that MA\u2010induced learning deficits can be dissociated from drug\u2010induced increases in plasma corticosterone or hyperthermia, but co\u2010occur with dopamine and serotonin reductions. Synapse 64:773\u2013785, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/syn.20784","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T15:17:50Z","timestamp":1269875870000},"page":"773-785","source":"Crossref","is-referenced-by-count":23,"title":["(+)\u2010Methamphetamine\u2010induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia"],"prefix":"10.1002","volume":"64","author":[{"given":"Nicole R.","family":"Herring","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Gudelsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles V.","family":"Vorhees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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