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The aim of the present study was to validate a Logan reference tissue method as an analytical method for in vivo binding of [<jats:sup>11<\/jats:sup>C](+)3\u2010MPB to mAChR. Seven monkeys (<jats:italic>Macaca mulatta<\/jats:italic>) underwent [<jats:sup>11<\/jats:sup>C](+)3\u2010MPB PET scans with an arterial blood sampling. Logan plot with arterial input function (Logan arterial input method) was performed to determine the binding potential (BP<jats:sub>ND<\/jats:sub>). The BP<jats:sub>ND<\/jats:sub>was also determined by Logan plot with the cerebellum as the reference region (Logan reference tissue method). BP<jats:sub>ND<\/jats:sub>values determined by Logan arterial input method and Logan reference tissue method showed a significant linear relationship. The present study suggests that the cerebellum is a suitable reference region for quantification of mAChR in the living brain with [<jats:sup>11<\/jats:sup>C](+)3\u2010MPB and PET. 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