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SDV rats showed a decrease in the electrical stimuli\u2010induced hind limb\u2010flexion threshold at 250 Hz, but showed no similar effect at 5 or 2000 Hz, which indicated that lumbar primary afferent A\u03b4 sensitivity was enhanced in SDV rats. The whole\u2010cell patch\u2010clamp technique also revealed the hyper\u2010excitability of acutely dissociated medium\u2010sized lumbar dorsal root ganglion (DRG) neurons isolated from SDV rats. The contribution of changes in voltage\u2010dependent potassium (Kv) channels was assessed, and transient A\u2010type K<jats:sup>+<\/jats:sup>(<jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub>) current density was apparently decreased. Moreover, Kv4.3 immunoreactivity in medium\u2010sized DRG neurons was significantly reduced in SDV rats compared to sham. These results indicate that SDV causes hyper\u2010excitability of lumbar primary A\u03b4 afferent neurons, which may be induced along with suppressing<jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub>currents via the decreased expression of Kv4.3. Thus, peripheral A\u03b4 neuroplasticity may contribute to the chronic lower limb pain caused by SDV. Synapse, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/syn.20982","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T18:37:07Z","timestamp":1315593427000},"page":"95-105","source":"Crossref","is-referenced-by-count":7,"title":["Subdiaphragmatic vagotomy increases the sensitivity of lumbar A\u03b4 primary afferent neurons along with voltage\u2010dependent potassium channels in 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