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We hypothesized that the ability to perform the activities of daily living (ADL) is correlated with the density of vesicular acetylcholine transporters in the striata of women with RTT. The density of the vesicular acetylcholine transporters in the living human brain can be estimated by single\u2010photon emission\u2010computed tomography (SPECT) after the administration of (\u2212)\u20105\u2010[<jats:sup>123<\/jats:sup>I]iodobenzovesamicol ([<jats:sup>123<\/jats:sup>I]IBVM). Twenty\u2010four hours following the intravenous injection of \u223c333 MBq (9 mCi) [<jats:sup>123<\/jats:sup>I]IBVM, four women with RTT and nine healthy adult volunteer control participants underwent SPECT brain scans for 60 min. The Vesicular Acetylcholine Transporter Binding Site Index (Kuhl et al., 1994), a measurement of the density of vesicular acetylcholine transporters, was estimated in the striatum and the reference structure, the cerebellum. The women with RTT were assessed for certain ADL. Although the striatal Vesicular Acetylcholine Transporter Binding Site Index was not significantly lower in RTT (5.2 \u00b1 0.9) than in healthy adults (5.7 \u00b1 1.6), RTT striatal Vesicular Acetylcholine Transporter Binding Site Indices and ADL scores were linearly associated (ADL = 0.89*(Vesicular Acetylcholine Transporter Binding Site Index) + 4.5;<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>= 0.93;<jats:italic>P<\/jats:italic>&lt; 0.01), suggesting a correlation between the ability to perform ADL and the density of vesicular acetylcholine transporters in the striata of women with RTT. [<jats:sup>123<\/jats:sup>I]IBVM is a promising tool to characterize the pathophysiological mechanisms of RTT and other neurodevelopmental disabilities. Synapse, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/syn.21515","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T09:06:04Z","timestamp":1325063164000},"page":"471-482","source":"Crossref","is-referenced-by-count":16,"title":["Correlation of the vesicular acetylcholine transporter densities in the striata to the clinical abilities of women with rett syndrome"],"prefix":"10.1002","volume":"66","author":[{"given":"James Robert","family":"Bra\u0161i\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genila","family":"Bibat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marybeth E.","family":"Yablonski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Semih","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Guevara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massoud","family":"Stephane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean Foster","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakkubai","family":"Naidu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(200022)97:2<147::AID-AJMG6>3.0.CO;2-O"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200005)47:5<670::AID-ANA20>3.0.CO;2-F"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00332-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10027"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200082401"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0290"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0299"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.53"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304752.50773.ec"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072553"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(96)02251-6"},{"issue":"7","key":"e_1_2_6_14_1","first-page":"S118","article-title":"Determination of presynaptic acetylcholine terminal densities and its clinical correlation in Rett's syndrome","volume":"54","author":"Bibat GM","year":"2003","journal-title":"Ann Neurol"},{"issue":"5","key":"e_1_2_6_15_1","first-page":"A28","article-title":"Reduced acetylcholine vesicular transport in adults with Rett syndrome: Clinical correlation and therapeutic implications","volume":"62","author":"Bibat GM","year":"2004","journal-title":"Neurology"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.1997.0711"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.2003.93.1.151"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.95.3.859-861"},{"key":"e_1_2_6_19_1","first-page":"830","article-title":"Correlation of the ability to perform the activities of daily living (ADL) to a density index of acetylcholine (ACh) vesicular transporters in the striata of women with Rett syndrome (RTT)","volume":"51","author":"Bra\u0161i\u0107 JR","year":"2010","journal-title":"J Nucl Med"},{"key":"e_1_2_6_20_1","unstructured":"Bra\u0161i\u0107JR BradfordL KalaffA SimsLP AlexanderM MainiA DoganAS ChunTT BibatG NaiduS CoenraadsM WongDF.2002. 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