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EB\u20101020 preferentially inhibited monoamine reuptake in cloned cell lines transfected with human transporters with IC<jats:sub>50<\/jats:sub>values of 6 and 38, respectively, for NE and DA transporters. In microdialysis studies, EB\u20101020 markedly increased NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increased DA extracellular concentrations in the striatum to 400% of baseline concentrations. Behavioral studies demonstrated that EB\u20101020 dose\u2010dependently decreased immobility in the mouse tail suspension test of depression to 13% of control levels, and did not stimulate locomotor activity in adult rats in the optimal dose range. EB\u20101020 dose\u2010dependently inhibited locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6\u2010hydroxydopamine (100 \u03bcg intracisternally) as neonates; a well\u2010established animal model for attention\u2010deficit hyperactivity disorder (ADHD). These data suggest that EB\u20101020 mediates its actions by stimulating NE and DA neurotransmission, which are typically impaired in ADHD. Synapse, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/syn.21538","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T04:43:37Z","timestamp":1328157817000},"page":"522-532","source":"Crossref","is-referenced-by-count":64,"title":["Pharmacological characterization of the norepinephrine and dopamine reuptake inhibitor EB\u20101020: Implications for treatment of attention\u2010deficit hyperactivity disorder"],"prefix":"10.1002","volume":"66","author":[{"given":"Frank P.","family":"Bymaster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Golembiowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kowalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong 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