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CUMI\u2010101 has agonistic properties in human embryonic kidney 293 cells transfected with human recombinant 5\u2010HT<jats:sub>1A<\/jats:sub> receptors (Hendry et al. [2011] Nucl Med Biol 38:273\u2013277; Kumar et al. [2006] J Med Chem 49:125\u2013134) and has previously been demonstrated to be sensitive to bolus citalopram in monkeys (Milak et al. [2011] J Cereb Blood Flow Metab 31:243\u2013249). We studied six healthy individuals. Two PET\u2010scans were performed on the same day in each individual before and after constant infusion of citalopram (0.15 mg\/kg). The imaging data were analyzed using two tissue compartment kinetic modeling with metabolite corrected arterial input and Simplified Reference Tissue Modeling using cerebellum as a reference region. There was no significant difference in regional distribution volume or non\u2010displaceable binding potential values before and after citalopram infusion. The mean receptor occupancy was 0.03 (range \u22120.14 to 0.17). Our data imply that [<jats:sup>11<\/jats:sup>C]CUMI\u2010101 binding is not sensitive to citalopram infusion in humans. Synapse, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/syn.21579","type":"journal-article","created":{"date-parts":[[2012,6,23]],"date-time":"2012-06-23T07:07:11Z","timestamp":1340435231000},"page":"880-884","source":"Crossref","is-referenced-by-count":35,"title":["No change in [<sup>11<\/sup>C]CUMI\u2010101 binding to 5\u2010HT<sub>1A<\/sub> receptors after intravenous citalopram in human"],"prefix":"10.1002","volume":"66","author":[{"given":"Lars H.","family":"Pinborg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette 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