{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:31:15Z","timestamp":1790397075334,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the increased prevalence of cocaine use and abuse in males when compared with females, possible effects of paternal cocaine exposure on biobehavioral development have received little attention. We therefore exposed male mice to cocaine (20 mg\/kg, i.p.) or vehicle for 10 weeks and then used those mice as sires. We then behaviorally phenotyped the F1 offspring to assess the consequences of paternal cocaine exposure on brain function. We report the presence of a subtle but significant increase in immobility in the tail suspension test, a measure of behavioral depression, following paternal cocaine. Body weight was also significantly decreased in paternal cocaine\u2010exposed offspring. Other aspects of neurobehavioral function, including locomotor activity, anxiety, and learning and memory, were not affected by paternal cocaine history. These data suggest alterations in brain systems and\/or circuitry underlying mood regulation in the offspring of cocaine\u2010using fathers. Synapse 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/syn.21582","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T03:30:49Z","timestamp":1342668649000},"page":"902-908","source":"Crossref","is-referenced-by-count":58,"title":["Subtle biobehavioral effects produced by paternal cocaine exposure"],"prefix":"10.1002","volume":"66","author":[{"given":"Catherine E.","family":"Killinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg D.","family":"Stanwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"335","article-title":"Paternal behavioral mutagenesis","volume":"10","author":"Abel EL","year":"1989","journal-title":"Neurotoxicology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(91)91168-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00925.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1988.tb00205.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1989.tb00051.x"},{"key":"e_1_2_7_7_1","first-page":"309","article-title":"Cocaine depresses the canine myocardium","volume":"28","author":"Abel FL","year":"1989","journal-title":"Circ Shock"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.05.026"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016715"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(01)00181-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.01.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(75)90173-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336824"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(03)00017-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0022-3565(25)09581-3","article-title":"Adverse effects of paternal opiate exposure on offspring development and sensitivity to morphine\u2010induced analgesia","volume":"273","author":"Cicero TJ","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/20.2.139"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118514109"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.05.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2010.06.007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2478\/s13382-011-0019-x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(02)00196-4"},{"key":"e_1_2_7_22_1","first-page":"739","article-title":"Effects of limited paternal exposure to xenobiotic agents on the development of progeny","volume":"7","author":"Friedler G","year":"1985","journal-title":"Neurobehav Toxicol Teratol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00286-9"},{"key":"e_1_2_7_24_1","first-page":"23","article-title":"Behavioral effects in offspring of male mice injected with opioids prior to mating","volume":"11","author":"Friedler G","year":"1979","journal-title":"Pharmacol Biochem Behav"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66654-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.05.006"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.08.017"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.06.006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.12.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.12.010"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90141-G"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00185-8"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.112"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09736.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(90)90095-L"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(99)00024-0"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.01.014"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1701"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-200506000-00008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.144.3625.1469"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579499002278"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036340"},{"key":"e_1_2_7_43_1","volume-title":"Results from the 2002 National Survey on Drug Use and Health: National findings","author":"Office of Applied Studies","year":"2003"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.9.1026"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.05.003"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(96)00121-3"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4591-06.2007"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20364"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.5.430"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.06.010"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2598"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1975.36.1395"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199502000-00010"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244324"},{"key":"e_1_2_7_55_1","first-page":"1036","article-title":"Distribution of tritiated cocaine in selected genital and nongenital organs following administration to male mice","volume":"116","author":"Yazigi RA","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_56_1","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1001\/jama.1991.03470140068026","article-title":"Demonstration of specific binding of cocaine to human spermatozoa","volume":"266","author":"Yazigi RA","year":"1991","journal-title":"JAMA"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.21582","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.21582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T21:26:34Z","timestamp":1743801994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.21582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,27]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/syn.21582"],"URL":"https:\/\/doi.org\/10.1002\/syn.21582","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,27]]}}}