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Glial cytoplasmic inclusions (GCIs) containing alpha\u2010synuclein represent the hallmark of MSA and are recapitulated in mice expressing alpha\u2010synuclein in oligodendrocytes. To assess if oligodendroglial expression of human wild\u2010type alpha\u2010synuclein in mice (proteolipid promoter, PLP\u2010SYN) could be associated with age\u2010related deficits, PLP\u2010SYN and wild\u2010type mice were assessed for motor function, brain morphometry, striatal levels of dopamine and metabolites, dopaminergic loss, and distribution of GCIs. PLP\u2010SYN displayed age\u2010related impairments on a beam\u2010traversing task. MRI revealed a significantly smaller brain volume in PLP\u2010SYN mice at 12 months, which further decreased at 18 months together with increased volume of ventricles and cortical atrophy. The distribution of GCIs was reminiscent of MSA with a high burden in the basal ganglia. Mild dopaminergic cell loss was associated with decreased dopamine turnover at 18 months. These data indicate that PLP\u2010SYN mice may recapitulate some of the progressive features of MSA and deliver endpoints for the evaluation of therapeutic strategies. <jats:bold>Synapse 68:98\u2013106, 2014.<\/jats:bold> \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/syn.21719","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T10:10:07Z","timestamp":1383214207000},"page":"98-106","source":"Crossref","is-referenced-by-count":36,"title":["Age\u2010related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy"],"prefix":"10.1002","volume":"68","author":[{"given":"P.O.","family":"Fernagut","sequence":"first","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 de Bordeaux UMR 5293, F\u201033000 Bordeaux France"},{"name":"CNRS Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives UMR 5293, F\u201033000 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.G.","family":"Meissner","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 de Bordeaux UMR 5293, F\u201033000 Bordeaux France"},{"name":"CNRS Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives UMR 5293, F\u201033000 Bordeaux France"},{"name":"Service de Neurologie CHU de Bordeaux F\u201033604 Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Biran","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique des Syst\u00e8mes Biologiques Universit\u00e9 de Bordeaux UMR 5536, Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fantin","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 de Bordeaux UMR 5293, F\u201033000 Bordeaux France"},{"name":"Section of Pharmacology Department of Experimental and Clinical Medicine University of Ferrara Ferrara Italy"},{"name":"Neuroscience Center and Istituto Nazionale di Neuroscience University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bassil","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 de Bordeaux UMR 5293, F\u201033000 Bordeaux France"},{"name":"CNRS Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives UMR 5293, F\u201033000 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Franconi","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9sonance Magn\u00e9tique des Syst\u00e8mes Biologiques Universit\u00e9 de Bordeaux UMR 5536, Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tison","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives Universit\u00e9 de Bordeaux UMR 5293, F\u201033000 Bordeaux France"},{"name":"CNRS Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives UMR 5293, F\u201033000 Bordeaux France"},{"name":"Service de Neurologie CHU de Bordeaux F\u201033604 Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff MD","year":"2004","journal-title":"Biophotonics Int"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00637.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10502"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2652"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-004-0206-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.6379"},{"issue":"6","key":"e_1_2_6_9_1","first-page":"1823","article-title":"Striatonigral degeneration","volume":"113","author":"Fearnley JM","year":"1990","journal-title":"A clinicopathological study. 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