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We hypothesize that the sex differences in hypertension are related to differential AngII\u2010induced changes in postsynaptic trafficking of the essential NMDA receptor GluN1 subunit and ROS production in PVN cells expressing angiotensin Type 1a receptor (AT1aR). We tested this hypothesis using slow\u2010pressor (14\u2010day) infusion of AngII (600 ng\/kg\/min) in mice, which elicits hypertension in males but not in young females. Two\u2010month\u2010old male and female transgenic mice expressing enhanced green fluorescent protein (EGFP) in AT1aR\u2010containing cells were used. In males, but not in females, AngII increased blood pressure and ROS production in AT1aR\u2013EGFP PVN cells at baseline and following NMDA treatment. Electron microscopy showed that AngII increased cytoplasmic and total GluN1\u2013silver\u2010intensified immunogold (SIG) densities and induced a trend toward an increase in near plasmalemmal GluN1\u2013SIG density in AT1aR\u2013EGFP dendrites of males and females. Moreover, AngII decreased dendritic area and diameter in males, but increased dendritic area of small (&lt;1 \u00b5m) dendrites and decreased diameter of large (&gt;1 \u00b5m) dendrites in females. Fluorescence microscopy revealed that AT1aR and estrogen receptor \u03b2 do not colocalize, suggesting that if estrogen is involved, its effect is indirect. These data suggest that the sexual dimorphism in AngII\u2010induced hypertension is associated with sex differences in ROS production in AT1aR\u2010containing PVN cells but not with postsynaptic NMDA receptor trafficking.\n                    <jats:bold>Synapse 69:148\u2013165, 2015.<\/jats:bold>\n                    \u2003\u00a9 2015 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/syn.21800","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T02:11:29Z","timestamp":1420510289000},"page":"148-165","source":"Crossref","is-referenced-by-count":29,"title":["Female protection from slow\u2010pressor effects of angiotensin II involves prevention of ROS production independent of NMDA receptor trafficking in hypothalamic neurons expressing angiotensin 1A receptors"],"prefix":"10.1002","volume":"69","author":[{"given":"Jose","family":"Marques\u2010Lopes","sequence":"first","affiliation":[{"name":"Brain and Mind Research Institute Weill 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