{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:27:44Z","timestamp":1788384464424,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stockholm Brain Institute"},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"crossref"}]},{"name":"AZ\/KI Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The serotonin 5\u2010HT<jats:sub>1B<\/jats:sub> receptor subtype is involved in the modulation of serotonin release and is a target of interest for neuroreceptor imaging. Previous studies have shown that the serotonin system is affected in Parkinson's disease (PD). Cognitive function, frequently impaired in PD, has been linked to the serotonin system. The aim of this study was to examine whether 5\u2010HT<jats:sub>1B<\/jats:sub> receptor availability in the brain of healthy subjects and PD patients is associated with measures of cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve control subjects and ten PD patients with normal mini\u2010mental state examination scores were included in this study. Cognitive function was evaluated by assessment of semantic, episodic, and working memory, as well as fluency and visual attention. Creative ability, a measure of divergent thinking, was examined with the alternative uses of objects task. PET measurements were performed with the 5\u2010HT<jats:sub>1B<\/jats:sub> receptor\u2010radioligand [<jats:sup>11<\/jats:sup>C]AZ10419369 using the HRRT system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PD patients showed statistically significant lower measures of semantic and episodic memory, as well as creative ability, compared with control subjects. Statistically significant positive correlations were found in control subjects between creative ability and average 5\u2010HT<jats:sub>1B<\/jats:sub> receptor availability in grey matter, and in PD patients between scores of Beck Depression Inventory\u2010II and creative ability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Though creativity has been conventionally linked to dopamine function, our findings in control subjects suggest a link between 5\u2010HT<jats:sub>1B<\/jats:sub> receptor availability and creative ability. In PD patients, creative ability was significantly associated with depressive symptoms but not with 5\u2010HT<jats:sub>1B<\/jats:sub> receptor availability. This finding deserves further investigation in future studies. <jats:bold>Synapse 69:365\u2013374, 2015.<\/jats:bold> \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/syn.21823","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T07:47:29Z","timestamp":1429861649000},"page":"365-374","source":"Crossref","is-referenced-by-count":25,"title":["5\u2010<scp>HT<\/scp><sub>1B<\/sub> receptor imaging and cognition: A positron emission tomography study in control subjects and parkinson's disease patients"],"prefix":"10.1002","volume":"69","author":[{"given":"Andrea","family":"Varrone","sequence":"first","affiliation":[{"name":"Karolinska Institutet, Department of Clinical Neuroscience Centre for Psychiatry Research Stockholm Sweden"},{"name":"Stockholm Brain Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"per","family":"Svenningsson","sequence":"additional","affiliation":[{"name":"Stockholm 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