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Transferring this technology to other neurotransmitter systems has proved less fruitful. The serotonergic system (5\u2010HT) is one such system. 5\u2010HT has been implicated in a wide range of brain functions and their disorders. The ability to measure 5\u2010HT using this technique would be invaluable. In this article, we explore the key pharmacological features of current radiotracers for 5\u2010HT receptors that might be sensitive to endogenous 5\u2010HT. We also estimate the likely brain concentrations of the current available tranche of agents that might be used to enhance synaptic 5\u2010HT concentration, so taking into account the potential for these to interact with the receptors directly and produce a spurious displacement signal.<jats:bold>Synapse 69:505\u2013511, 2015<\/jats:bold>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/syn.21835","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T08:19:46Z","timestamp":1434701986000},"page":"505-511","source":"Crossref","is-referenced-by-count":19,"title":["Optimising<scp>PET<\/scp>approaches to measuring 5\u2010<scp>HT<\/scp>release in human brain"],"prefix":"10.1002","volume":"69","author":[{"given":"Robin J.","family":"Tyacke","sequence":"first","affiliation":[{"name":"Centre for Neuropsychopharmacology Division of Brain Sciences Hammersmith Hospital, Imperial College London W12 0NN United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Nutt","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychopharmacology Division of Brain Sciences Hammersmith Hospital, Imperial College London W12 0NN United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.08.006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10037-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00266-X"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-813X(03)00030-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/2191-219X-3-19"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189414"},{"key":"e_1_2_5_8_1","article-title":"The Effects of Acutely Administered 3,4\u2010Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level\u2010Dependent Resting State Functional Connectivity","author":"Carhart\u2010Harris RL","journal-title":"Biol Psychiatry"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.01.027"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb07313.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1686-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0722127.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.195"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.03.021"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.01.003"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-004-0951-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0324-y"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200003000-00001"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.150722"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0022-3565(24)34877-3","article-title":"Cardiovascular and neuroendocrine effects and pharmacokinetics of 3, 4\u2010methylenedioxymethamphetamine in humans","volume":"290","author":"Mas M","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000704"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0022-3565(24)29415-5","article-title":"S33005, a novel ligand at both serotonin and norepinephrine transporters: I. 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