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Postsynaptic calcium influx promotes EC synthesis and depression of neurotransmission. ECs can be degraded by a hydrolytic and an oxidative pathway, the latter via the enzyme cyclooxygenase 2 (COX\u20102). Hyperactivity in the DCN is related to the development of tinnitus, which can be induced by high doses of salicylate, a COX\u20102 inhibitor. Since EC\u2010dependent plasticity in the DCN can affect its excitation\u2010inhibition balance, we investigated the impact of inhibitors of both oxidative and hydrolytic EC metabolism on the DSE from the synapses between the parallel fibers and cartwheel neurons (PF\u2010CW) in the DCN. We found that inhibitors of COX\u20102 (ibuprofen and indomethacin) did not alter DSE at the PF\u2010CW synapse. Salicylate also did not alter DSE. However, we found that inhibitors of the hydrolytic pathway did not affect DSE magnitude, but surprisingly speeded DSE decay. We conclude that oxidative EC degradation in the PF\u2010CW synapse is not relevant for termination of DSE and are probably not important for controlling this form of synaptic plasticity in the DCN PF\u2010CW synapse. The lack of effect on DSE of high doses of salicylate also suggests that it is not acting by increasing DSE in the PF\u2010CWC synapse. However, the counter intuitive effect of the hydrolytic inhibitors shows that increasing EC on this synapse have more complex effects on DSE.<\/jats:p>","DOI":"10.1002\/syn.21954","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T17:49:02Z","timestamp":1482256142000},"source":"Crossref","is-referenced-by-count":3,"title":["Inhibitors of oxidative and hydrolytic endocannabinoid degradation do not enhance depolarization\u2010induced suppression of excitation on dorsal cochlear nucleus glycinergic neurons"],"prefix":"10.1002","volume":"71","author":[{"given":"Jo\u00e3o","family":"Zugaib","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"},{"name":"Research Group on the Dynamics of the Neuromusculoskeletal System, Bahiana School of Medicine and Public Health Salvador Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-3342","authenticated-orcid":false,"given":"Ricardo M.","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.01.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01828-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1523\/JNEUROSCI.22-06-02383.2002","article-title":"Elevated Fusiform Cell Activity in the Dorsal Cochlear Nucleus of Chinchillas with Psychophysical Evidence of Tinnitus","volume":"22","author":"Brozosky T. 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