{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:58:33Z","timestamp":1762376313766,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21 MH096255"],"award-info":[{"award-number":["R21 MH096255"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arachidonic acid (AA) is involved in signal transduction, neuroinflammation, and production of eicosanoid metabolites. The AA brain incorporation coefficient (K*) is quantifiable <jats:italic>in vivo<\/jats:italic> using [<jats:sup>11<\/jats:sup>C]AA positron emission tomography, although repeatability remains undetermined. We evaluated K* estimates obtained with population\u2010based metabolite correction (PBMC) and image\u2010derived input function (IDIF) in comparison to arterial blood\u2010based estimates, and compared repeatability. Eleven healthy volunteers underwent a [<jats:sup>11<\/jats:sup>C]AA scan; five repeated the scan 6 weeks later, simulating a pre\u2010 and post\u2010treatment study design. For all scans, arterial blood was sampled to measure [<jats:sup>11<\/jats:sup>C]AA plasma radioactivity. Plasma [<jats:sup>11<\/jats:sup>C]AA parent fraction was measured in 5 scans. K* was quantified using both blood data and IDIF, corrected for [<jats:sup>11<\/jats:sup>C]AA parent fraction using both PBMC (from published values) and individually measured values (when available). K* repeatability was calculated in the test\u2010retest subset. K* estimates based on blood and individual metabolites were highly correlated with estimates using PBMC with arterial input function (<jats:italic>r<\/jats:italic>\u2009=\u20090.943) or IDIF (<jats:italic>r<\/jats:italic>\u2009=\u20090.918) in the subset with measured metabolites. In the total dataset, using PBMC, IDIF\u2010based estimates were moderately correlated with arterial input function\u2010based estimates (<jats:italic>r<\/jats:italic>\u2009=\u20090.712). PBMC and IDIF\u2010based K* estimates were \u223c6.4% to \u223c11.9% higher, on average, than blood\u2010based estimates. Average K* test\u2010retest absolute percent difference values obtained using blood data or IDIF, assuming PBMC for both, were between 6.7% and 13.9%, comparable to other radiotracers. Our results support the possibility of simplified [<jats:sup>11<\/jats:sup>C]AA data acquisition through eliminating arterial blood sampling and metabolite analysis, while retaining comparable repeatability and validity.<\/jats:p>","DOI":"10.1002\/syn.22018","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T16:04:55Z","timestamp":1510848295000},"source":"Crossref","is-referenced-by-count":8,"title":["[<sup>11<\/sup>C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-0676","authenticated-orcid":false,"given":"Francesca","family":"Zanderigo","sequence":"first","affiliation":[{"name":"Molecular Imaging and Neuropathology Division New York State Psychiatric Institute New York New York"},{"name":"Department of Psychiatry Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeona","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dileep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division New York State Psychiatric Institute New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Nikolopoulou","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. David","family":"Mozley","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paresh J.","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Schlyer","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley I.","family":"Rapoport","sequence":"additional","affiliation":[{"name":"National Institute on Aging Bethesda MSC 2292 Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Oquendo","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division New York State Psychiatric Institute New York New York"},{"name":"Department of Psychiatry Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shankar","family":"Vallabhajosula","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. John","family":"Mann","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division New York State Psychiatric Institute New York New York"},{"name":"Department of Psychiatry Columbia University New York New York"},{"name":"Department of Radiology Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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