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Most studies though have focused on psychostimulants and little is known about the neuroadaptive response of these two lines to cannabinoids. This study investigated the effects of chronic exposure to \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (THC) on dopamine D<jats:sub>2\/3<\/jats:sub>receptor (D<jats:sub>2\/3<\/jats:sub>R) availabilities and functional sensitivity in the mesostriatal system of RHA and RLA rats. At baseline, RLA rats exhibited higher densities of mesostriatal D2\/3R but lower levels of striatal CB<jats:sub>1<\/jats:sub>R mRNA and displayed a lower locomotor response to acute THC as compared to RHAs. Following chronic THC treatment, striking changes in D<jats:sub>2\/3<\/jats:sub>R signaling were observed in RLA but not in RHA rats, namely an increased availability and functional supersensitivity of striatal D<jats:sub>2\/3<\/jats:sub>R, as evidenced by a supersensitive psychomotor response to the D<jats:sub>2\/3<\/jats:sub>R agonist quinpirole. Moreover, in RLA rats, the lower was the locomotor response to acute THC, the higher was the psychomotor response to quinpirole following chronic THC. These results showing a greater neuroadaptive response of RLA vs. RHA rats to chronic THC thus contrast with previous studies showing a resistance to neuroadaptive response of RLAs to psychostimulants, This suggests that, contrasting with their low proneness to psychostimulant drug\u2010seeking, RLAs may exhibit a heightened proneness to cannabinoid drug\u2010seeking as compared to RHA rats.<\/jats:p>","DOI":"10.1002\/syn.22023","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T13:22:42Z","timestamp":1513689762000},"source":"Crossref","is-referenced-by-count":5,"title":["Different effects of chronic THC on the neuroadaptive response of dopamine D2\/3 receptor\u2010mediated signaling in roman high\u2010 and roman low\u2010avoidance rats"],"prefix":"10.1002","volume":"72","author":[{"given":"Benjamin B.","family":"Tournier","sequence":"first","affiliation":[{"name":"Department of Mental Health and Psychiatry, Laboratory for Translational Imaging in Psychiatric Neuroscience University Hospitals of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dimiziani","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Psychiatry, Laboratory for Translational Imaging in Psychiatric Neuroscience University Hospitals of Geneva Geneva Switzerland"},{"name":"Department of Psychiatry University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios","family":"Tsartsalis","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Psychiatry, Laboratory for Translational Imaging in Psychiatric Neuroscience University Hospitals of Geneva Geneva Switzerland"},{"name":"Department of Psychiatry University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Millet","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Psychiatry, Laboratory for Translational Imaging in Psychiatric Neuroscience University Hospitals of Geneva Geneva Switzerland"},{"name":"Department of Psychiatry University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-6599","authenticated-orcid":false,"given":"Nathalie","family":"Ginovart","sequence":"additional","affiliation":[{"name":"Department of Mental Health and Psychiatry, Laboratory for Translational Imaging in Psychiatric Neuroscience University Hospitals of Geneva Geneva Switzerland"},{"name":"Department of Psychiatry University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-09-03401.2000"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246977"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.027"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12139"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0022-3565(25)22697-0","article-title":"6\u2010hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1\u2010 and D2\u2010dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding","volume":"240","author":"Breese G. 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