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Demyelination is associated with electrophysiological alterations and the mutant had a progressive astrocytosis. The illness is associated with change in cytokine levels and in the expression of different nitric oxide synthase and concomitantly lipoperoxidation in several areas of the brain. However, until now there has been no detailed anatomical analysis of neurons in this mutant. The aim of this study was to analyze the dendritic morphology in the hippocampus using Golgi\u2010Cox staining and spatial memory through Morris water maze test in young adult (3 months old) <jats:italic>taiep<\/jats:italic> rats and compare them with normal Sprague\u2010Dawley. Our results showed that <jats:italic>taiep<\/jats:italic> rats have altered dendritic tree morphology in pyramidal neurons in the CA1 field of the hippocampus, but not in the CA3 region. These morphological changes did not produce a concomitant deficit in spatial memory acquisition or recall at this early stage of the disease. Our results suggest that impairment of dendritic morphology in the CA1 field of the hippocampus is a landmark of the pathology of this progressive multiple sclerosis model.<\/jats:p>","DOI":"10.1002\/syn.22024","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T16:58:02Z","timestamp":1515689882000},"source":"Crossref","is-referenced-by-count":3,"title":["Juvenile <i>Taiep<\/i> rats have shorter dendritic trees in the dorsal field of the hippocampus without spatial learning disabilities"],"prefix":"10.1002","volume":"72","author":[{"given":"Adriana B.","family":"Silva\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"Faculty of Biological Sciences Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores A.","family":"Bravo\u2010Duran","sequence":"additional","affiliation":[{"name":"Faculty of Biological Sciences Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-1141","authenticated-orcid":false,"given":"Jose R.","family":"Eguibar","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  M\u00e9xico"},{"name":"Research Office, Vice\u2010rectory of Research and Postgraduate Studies Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-2665","authenticated-orcid":false,"given":"Carmen","family":"Cortes","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla  M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199904060-00004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21109"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20188"},{"key":"e_1_2_8_5_1","unstructured":"Cort\u00e9s M. C. Silva Y. &Eguibar J. R.(2015 October).The absence seizures in the myelin mutant taiep rat are sexually\u2010 and circadian\u2010 dependent. 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