{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:16:12Z","timestamp":1788174972251,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Establishment and Operation of Research Infrastructure for Radioisotope Application funded by Ministry of Science and ICT, Republic of Korea","award":["50461-2017"],"award-info":[{"award-number":["50461-2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT and <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head\u2010to\u2010head comparisons between <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT and <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT. Therefore, in this study, <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT\/CT was compared with <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT\/CT and <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT\/CT and <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT\/CT and <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\/CT showed a positive correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.78, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). However, the mean SBRs on <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\/CT were higher than those on <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT\/CT (2.19\u00a0\u00b1\u00a0.87 and 1.22\u00a0\u00b1\u00a0.49, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). The PCRs in these two modalities were correlated with each other (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.71, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). The mean PCRs on <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\/CT were not significantly higher than those on <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT\/CT (1.31\u00a0\u00b1\u00a0.19 and 0.98\u00a0\u00b1\u00a0.06, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.06). These preliminary results indicate that the uptake of both <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT and <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\/CT relative to <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT SPECT\/CT.<\/jats:p>","DOI":"10.1002\/syn.22032","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T22:56:36Z","timestamp":1519772196000},"source":"Crossref","is-referenced-by-count":31,"title":["Head\u2010to\u2010head comparison of <sup>18<\/sup>F\u2010FP\u2010CIT and <sup>123<\/sup>I\u2010FP\u2010CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2051-3597","authenticated-orcid":false,"given":"Inki","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of RI convergence research Research Institute of Radiological and Medical Sciences, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Yeun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Hyun","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansol","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of RI convergence research Research Institute of Radiological and Medical Sciences, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyo Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of RI convergence research Research Institute of Radiological and Medical Sciences, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Yoon","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sogang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of RI convergence research Research Institute of Radiological and Medical Sciences, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhan","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Hyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of RI convergence research Research Institute of Radiological and Medical Sciences, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Hyuk","family":"Ahn","sequence":"additional","affiliation":[{"name":"Radiopharmaceutical Production Center Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ho","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea Cancer Center Hospital, Korea Institutes of Radiological and Medical Sciences Seoul 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