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In both animals and humans, dopamine (DA) function appears to be dysregulated in brain areas involved in the conditioned fear response(s) that underlie PTSD. In this study, we determined the effect of the selective DA D<jats:sub>3<\/jats:sub>receptor antagonists YQA14A (6.25, 12.5 and 25 mg\/kg i.p.) and SB\u2010277011A (6 mg\/kg i.p.) on tone\u2010induced fear (assessed by measuring freeze time) in a modified version of the single\u2010prolonged stress (SPS) model of PTSD in adult male Sprague\u2010Dawley rats. Rats pretreated with vehicle and then subjected to restraint stress, forced swim and random foot shock (SPS) in the presence of a distinctive tone, displayed a significantly increased tone\u2010induced contextual freeze time and fecal pellet mass following re\u2010exposure to the tone. Rats pretreated with a single i.p. injection of 6.25 or 12.5 mg\/kg of YQA14 or 6 mg\/kg of SB\u2010277011A showed significantly attenuated contextual freeze time in the presence of the tone when tested 14 days after exposure to SPS. Overall, our results indicate that selectively antagonizing DA D<jats:sub>3<\/jats:sub>receptors significantly decreases freezing time caused by an environment previously associated with stress. If our findings can be extrapolated to humans with PTSD, they suggest that DA D<jats:sub>3<\/jats:sub>receptors may play a role in the pathophysiology of PTSD, and may have therapeutic utility for the clinical management of PTSD.<\/jats:p>","DOI":"10.1002\/syn.22035","type":"journal-article","created":{"date-parts":[[2018,4,28]],"date-time":"2018-04-28T00:35:41Z","timestamp":1524875741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Selective dopamine D<sub>3<\/sub>receptor antagonism significantly attenuates stress\u2010induced immobility in a rat model of post\u2010traumatic stress disorder"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2503-2549","authenticated-orcid":false,"given":"Onarae V.","family":"Rice","sequence":"first","affiliation":[{"name":"Psychology Department, Neuroscience Program Furman University 3300 Poinsett Highway, Greenville South 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