{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:58:03Z","timestamp":1758970683664,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA026472"],"award-info":[{"award-number":["R01DA026472"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA025247"],"award-info":[{"award-number":["R01AA025247"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Phosphodiesterase\u201010a (PDE10a) is located exclusively in medium spiny neurons (MSN). Rodent studies show an increase in striatal MSN spine density following exposure to cocaine. These increases in MSN spine density are suggested to underlie neurobiological changes which contribute to cocaine self\u2010administration. No postmortem or imaging studies have confirmed this finding in humans. Here, we hypothesized an increase in the MSN marker PDE10a in subjects with cocaine use disorder (\u201ccocaine users\u201d) compared to controls. PDE10a availability was measured with [<jats:sup>11<\/jats:sup>C]IMA107 and positron emission tomography in 15 cocaine users and 15 controls matched for age, gender, and nicotine status. Cocaine users with no comorbid psychiatric, medical, or drug abuse disorders were scanned following two weeks of outpatient\u2010monitored abstinence. [<jats:sup>11<\/jats:sup>C]IMA107 binding potential relative to nondisplaceable uptake (BP<jats:sub>ND<\/jats:sub>) in the regions of interest was derived with the simplified reference tissue method. No significant effect of diagnosis on BP<jats:sub>ND<\/jats:sub> was demonstrated using linear mixed modeling with [<jats:sup>11<\/jats:sup>C]IMA107 BP<jats:sub>ND<\/jats:sub> as the dependent variable and regions of interest as a repeated measure. There were no significant relationships between BP<jats:sub>ND<\/jats:sub> and clinical rating scales. To the extent that PDE10a is a valid proxy for MSN spine density, these results do not support its increase in recently abstinent cocaine users.<\/jats:p>","DOI":"10.1002\/syn.22070","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T03:14:10Z","timestamp":1537586050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Imaging phosphodiesterase\u201010a availability in cocaine use disorder with [<sup>11<\/sup>C]IMA107 and PET"],"prefix":"10.1002","volume":"73","author":[{"given":"Savannah","family":"Tollefson","sequence":"first","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Gertler","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Himes","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Paris","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Kendro","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Lopresti","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Scott Mason","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-2850","authenticated-orcid":false,"given":"Rajesh","family":"Narendran","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2016.11.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.712135"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.057"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.047"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2147780"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00593-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0066"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511244103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881112447991"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300420"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10050748"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08121801"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.4.622"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200109000-00002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03808.1995"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11010126"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20566"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv219"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv214"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2518-08.2008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13855"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.131409"},{"issue":"5","key":"e_1_2_7_25_1","first-page":"904","article-title":"Correction for partial volume effects in PET: Principle and validation","volume":"39","author":"Rousset O. G.","year":"1998","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002391"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.66"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032654599"},{"issue":"1","key":"e_1_2_7_29_1","first-page":"204","article-title":"Kinetic analysis of [11C]\u2010IMA107, a novel PET radiotracer for PDE10A","volume":"55","author":"Searle G.","year":"2014","journal-title":"J Nuc Med"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2006.01.012"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.09.025"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.07.011"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/386830a0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.12.042"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.06.033"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.22070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.22070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T20:47:17Z","timestamp":1694810837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.22070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/syn.22070"],"URL":"https:\/\/doi.org\/10.1002\/syn.22070","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"type":"print","value":"0887-4476"},{"type":"electronic","value":"1098-2396"}],"subject":[],"published":{"date-parts":[[2018,9,27]]},"assertion":[{"value":"2018-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22070"}}