{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:52:42Z","timestamp":1759683162802,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Direcci\u00f3n General de Asuntos del Personal acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["DGAPA-UNAM IN201517","IN 201417"],"award-info":[{"award-number":["DGAPA-UNAM IN201517","IN 201417"]}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, M\u00e9xico","doi-asserted-by":"crossref","award":["(CONACyT, 251144 to EG and Frontera 57 to JB)"],"award-info":[{"award-number":["(CONACyT, 251144 to EG and Frontera 57 to JB)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Different corticostriatal suprathreshold responses in direct and indirect striatal projection neurons (SPNs) of rodents have been reported. Responses consist in prolonged synaptic potentials of polysynaptic and intrinsic origin, in which voltage\u2010gated Ca<jats:sup>2<\/jats:sup>\u207a currents play a role. Recording simultaneous Ca<jats:sup>2<\/jats:sup>\u207a imaging and voltage responses at the soma, while activating the corticostriatal pathway, we show that encoding of synaptic responses into trains of action potentials (APs) is different in SPNs: firing of APs in D1\u2010SPNs increase gradually, in parallel with Ca<jats:sup>2<\/jats:sup>\u207a entry, as a function of stimulus intensity. In contrast, D2\u2010SPNs attain a maximum number of evoked spikes at low stimulus intensities, Ca<jats:sup>2<\/jats:sup>\u207a entry is limited, and both remain the same in spite of increasing stimulus strength. Stimulus needs to reach certain intensity, to have propagated Ca<jats:sup>2<\/jats:sup>\u207a potentials to the soma plus a sudden step in Ca<jats:sup>2<\/jats:sup>\u207a entry, without changing the number of fired APs, phenomena never seen in D1\u2010SPNs. Constant firing in spite of changing stimulus, suggested the involvement of underlying inactivating potentials. We found that Ca\u1d653 currents contribute to Ca<jats:sup>2+<\/jats:sup> entry in both classes of SPNs, but have a more notable effect in D2\u2010SPNs, where a low\u2010threshold spike was disclosed. Blockade of Ca<jats:sub>V<\/jats:sub>3 channels retarded the steep rise in firing in D2\u2010SPNs. Inhibition block increased the number of spikes fired by D2\u2010SPNs, without changing firing in D1\u2010SPNs. These differences in synaptic integration enable a biophysical dissimilarity: dendritic inhibition appears to be more relevant for D2\u2010SPNs. This may imply distinctions in the set of interneurons affecting each SPN class.<\/jats:p>","DOI":"10.1002\/syn.22079","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T06:45:11Z","timestamp":1542091511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Differences in synaptic integration between direct and indirect striatal projection neurons: Role of Ca<sub>V<\/sub>3 channels"],"prefix":"10.1002","volume":"73","author":[{"given":"Brisa","family":"Garc\u00eda\u2010Vilchis","sequence":"first","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Serrano\u2010Reyes","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Arias\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagoberto","family":"Tapia","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Duhne","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-8163","authenticated-orcid":false,"given":"Jos\u00e9","family":"Bargas","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-1245","authenticated-orcid":false,"given":"Elvira","family":"Galarraga","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico City M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3908-07.2008"},{"key":"e_1_2_8_3_1","article-title":"Cortical stimulation relieves parkinsonian pathological activity in vitro","author":"Aparicio\u2010Ju\u00e1rez A.","year":"2017","journal-title":"European Journal of Neuroscience"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2013.00063"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"1229","article-title":"Functional comparison of corticostriatal and thalamostriatal postsynaptic responses in striatal neurons of the mouse","volume":"223","author":"Arias\u2010Garc\u00eda M. 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