{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:49:47Z","timestamp":1778712587570,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["I\u201026004"],"award-info":[{"award-number":["I\u201026004"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schizophrenia is a mental disorder characterized by positive symptoms, negative symptoms, and cognitive dysfunction. Phencyclidine (PCP)\u2014a N\u2010methyl\u2010D\u2010aspartate (NMDA) receptor antagonist\u2014induces symptoms indistinguishable from those of schizophrenia. A reduction of the phosphoprotein synapsin II has also been implicated in schizophrenia and has a well\u2010known role in the maintenance of the presynaptic reserve pool and vesicle mobilization. This study assessed the behavioral and biochemical outcomes of chronic NMDA receptor antagonism in rodents and its implications for the pathophysiology of schizophrenia. Sprague Dawley rats received saline or chronic PCP (5\u00a0mg\/kg\/day) for 14\u00a0days via surgically implanted Alzet\u00ae osmotic mini\u2010pumps. Following the treatment period, rats were tested with a series of behavioral paradigms, including locomotor activity, social interaction, and sensorimotor gating. Following behavioral assessment, the medial prefrontal cortex (mPFC) of all rats was isolated for synapsin II protein analysis. Chronic PCP treatment yielded a hyper\u2010locomotive state (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0256), reduced social interaction (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0005), and reduced pre\u2010pulse inhibition (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) in comparison to saline\u2010treated controls. Synapsin IIa (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and IIb (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0071) levels in the mPFC of chronically treated PCP rats were reduced in comparison to the saline group. Study results confirm that rats subject to chronic PCP treatment display behavioral phenotypes similar to established preclinical animal models of schizophrenia. Reduction of synapsin II expression in this context implicates the role of this protein in the pathophysiology of schizophrenia and sheds light on the longer\u2010term consequences of NMDA receptor antagonism facilitated by chronic PCP treatment.<\/jats:p>","DOI":"10.1002\/syn.22084","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T12:55:35Z","timestamp":1545656135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reduced expression of synapsin II in a chronic phencyclidine preclinical rat model of schizophrenia"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-457X","authenticated-orcid":false,"given":"Sharon","family":"Thomson","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Department of Psychiatry and Behavioral Neuroscience McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailey","family":"Dyck","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Psychiatry and Behavioral Neuroscience McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritesh","family":"Daya","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Psychiatry and Behavioral Neuroscience McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joella","family":"Ho","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Psychiatry and Behavioral Neuroscience McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Psychiatry and Behavioral Neuroscience McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Tian","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Psychiatry and Behavioral Neuroscience McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Psychiatry and Behavioral Neuroscience McMaster University Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950160008002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.01.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810350036005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014181"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.07.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.04.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.05.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63041568.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01104.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.06.110190.002245"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.05.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.01.029"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00586-T"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5293-12.2013"},{"issue":"5400","key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.283.5400.397","article-title":"Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity","volume":"283","author":"Gainetdinov R. R.","year":"1999","journal-title":"Science (New York, N.Y.)"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/379606a0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0924-08.2008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830220065010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.1.65"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.2.203"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.03.029"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/349697a0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80851-X"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90387-L"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00060-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01386.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19991215)285:4<360::AID-JEZ4>3.0.CO;2-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1582-z"},{"issue":"9","key":"e_1_2_8_30_1","first-page":"507","article-title":"Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia","volume":"32","author":"Lodge D.","year":"2011","journal-title":"Cell"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2515"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(95)02144-2"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00085-4"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81972-8"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v5.i3.260"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00033-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01700.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(99)00029-1"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00148-1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/620361"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.4.349"},{"issue":"1","key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00008877-199501000-00009","article-title":"Distinct effects of d\u2010amphetamine and phencyclidine on the social behaviour of rats","volume":"6","author":"Sams\u2010Dodd F.","year":"1995","journal-title":"Behavioural Pharmacology"},{"issue":"1","key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0893-133X(97)00200-5","article-title":"Effects of continuous D\u2010amphetamine and phencyclidine administration on social behaviour, stereotyped behaviour, and locomotor activity in rats","volume":"19","author":"Sams\u2010Dodd F.","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2013.6"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp132"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.5341"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00163-X"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.22084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.22084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/syn.22084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.22084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:51:47Z","timestamp":1694433107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.22084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,7]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/syn.22084"],"URL":"https:\/\/doi.org\/10.1002\/syn.22084","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,7]]},"assertion":[{"value":"2018-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22084"}}