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In male rats, fluoxetine inhibited the serotonin (5\u2010hydroxytryptamine, 5\u2010HT) transporter (SERT) which is reducing the immobility time in the repeated forced swimming test (rFST). The performance of female rats in this test is unknown. In this study, responses of male and female rats in the rFST under chronic treatment with fluoxetine and the function of SERT in their brains were examined. Wistar rats received oral fluoxetine (females: 0, 1, 2.5, or 5\u00a0mg\u00a0kg<jats:sup>\u20101<\/jats:sup>\u00a0day<jats:sup>\u20101<\/jats:sup>; males: 0 or 2.5\u00a0mg\u00a0kg<jats:sup>\u20101<\/jats:sup>\u00a0day<jats:sup>\u20101<\/jats:sup>; in sucrose 10%, 1.5\u00a0ml\/rat) 1 hr before the test daily for 12\u00a0days over the course of the rFST. rFST consisted of a 15 min pretest followed by 5 min sessions of swimming at 1 (test), 7 (retest 1), and 14 (retest 2) days later. SERT functioning was assessed by ex vivo assays of the frontal cortex and hippocampus of rats. Fluoxetine reduced immobility time of males in the rFST while it failed to do so in females. In vitro treatment with fluoxetine inhibited the uptake of 5\u2010HT of both sexes similarly, while in vivo chronic administration of fluoxetine failed to do so. In summary, rats responded to the chronic treatment with fluoxetine in a sexually dimorphic fashion during the rFST despite the functioning of SERT in their brains remaining equally unchanged. Hence, our data suggest that sexually dimorphic responses to fluoxetine in rFST may be unrelated to the function of SERT in rat brains.<\/jats:p>","DOI":"10.1002\/syn.22130","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T18:13:22Z","timestamp":1566843202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sexually dimorphic responses of rats to fluoxetine in the forced swimming test are unrelated to the function of the serotonin transporter in the brain"],"prefix":"10.1002","volume":"74","author":[{"given":"Karolina","family":"Domingues","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Centro de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Santa Catarina \u2013 UFSC Florian\u00f3polis Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia, Centro de Ci\u00eancias Biol\u00f3gicas Universidade Federal 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