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While most studies are aimed to striatal function, the cellular and molecular mechanisms underlying dopaminergic regulation in other nuclei of the BG are not well understood. Therefore, we set to analyze the dopaminergic modulation occurring in subthalamo\u2010nigral synapse, in both pars compacta (SNc) and pars reticulata (SNr) neurons, because these synapses are important for the integration of information previously processed in striatum and globus pallidus. In this study, electrophysiological and pharmacological evidence of dopaminergic modulation on glutamate release through calcium channels is presented. Using paired pulse ratio (PPR) measurements and selective blockers of these ionic channels, together with agonists and antagonists of DA D<jats:sub>2<\/jats:sub>\u2010like receptors, we found that blockade of the Ca<jats:sub>V<\/jats:sub>3 family occludes the presynaptic inhibition produced by the activation of DA receptors pharmacologically profiled as D<jats:sub>3<\/jats:sub>\u2010type in the STh\u2010SNc synapses. On the contrast, the blockade of Ca<jats:sub>V<\/jats:sub>2 channels, but not Ca<jats:sub>V<\/jats:sub>3, occlude with the effect of the D<jats:sub>3<\/jats:sub> agonist, PD 128907, in the STh\u2010SNr synapse. The functional role of this differential distribution of calcium channels that modulate the release of glutamate in the SN implies a fine adjustment of firing for both classes of neurons. Dopaminergic neurons of the SNc establish a DA tone within the SN based on the excitatory\/inhibitory inputs; such tone may contribute to processing information from subthalamic nucleus and could also be involved in pathological DA depletion that drives hyperexcitation of SNr neurons.<\/jats:p>","DOI":"10.1002\/syn.22149","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T04:39:25Z","timestamp":1579840765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential calcium channel\u2010mediated dopaminergic modulation in the subthalamonigral synapse"],"prefix":"10.1002","volume":"74","author":[{"given":"Angel A.","family":"Robles\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"Neurociencias FES Iztacala, UNAM Tlalnepantla de Baz 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