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However, the early events that trigger these changes are not understood well. We investigated short\u2010term and long\u2010term synaptic plasticity parameters and T\u2010type Ca<jats:sup>2+<\/jats:sup> channel activity changes in the early phase of a rat kindling model. Chronic pentylenetetrazole (PTZ) application was used in order to induce the kindling process in rats. The recordings were obtained from hippocampal slices in the CA1 region at 25th day of PTZ application. Tetraethylammonium was used in order to induce long\u2010term potentiation and T\u2010type Ca<jats:sup>2+<\/jats:sup> channel activity was assessed in the presence of mibefradil. We found that tetraethylammonium\u2010induced long\u2010term potentiation was not prevented by mibefradil in the kindling group in contrast to control group. We also found an increase in paired\u2010pulse ratios in the PTZ\u2010applied group. Our findings indicate an increase in the \u201cT\u2010type Ca<jats:sup>2+<\/jats:sup> channel component of LTP\u201d in the kindling group, which may be an early mechanism in epileptogenesis.<\/jats:p>","DOI":"10.1002\/syn.22155","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T02:55:39Z","timestamp":1585191339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T\u2010type Ca<sup>2+<\/sup> channel activity increases in rat hippocampal CA1 region during kindling epileptogenesis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-3638","authenticated-orcid":false,"given":"Erkan","family":"Aksoz","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacology Suleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yildirim","family":"Sara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pharmacology Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rustu","family":"Onur","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pharmacology Near East University Nicosia TRNC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"130","article-title":"The role of neuroinflammation in epileptogenesis and antiepileptogenic therapy targets directed to neuroinflammation","volume":"9","author":"Aksoz E.","year":"2018","journal-title":"SDU Journal of Health Science Institute"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/349067a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012373961-2.00008-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2010.00879.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00137-L"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1421-08.2008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012373961-2.00021-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.05.030"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2002.tb00439.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867320666131119152201"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/B978-012373961-2.00265-4","volume-title":"Encyclopedia of basic epilepsy research","author":"Silva F.","year":"2009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.03.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0937s58"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00254-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04190-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/2141020a0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3482"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/347477a0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90880-T"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80305-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2016.1238992"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9574"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012373961-2.00238-1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199746545.003.0081"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003046"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.3.1335"},{"issue":"1","key":"e_1_2_7_29_1","first-page":"302","article-title":"Mibefradil block of cloned T\u2010type calcium channels","volume":"295","author":"Martin R. 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