{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:14:07Z","timestamp":1785500047724,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation and oxidative stress play a key role in mediating the pathophysiology of hypoxic\u2010ischemic (HI) brain injury. Nrf2 is a transcriptional factor that contributes to the innate defense of the body against oxidative stress and inflammation. The current study investigated the effect of Nrf2 in neonatal HI brain injury using Nrf2<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Nrf2<jats:sup>\u2212\/\u2212<\/jats:sup> and wild\u2010type Nrf2<jats:sup>+\/+<\/jats:sup> mice on a C57BL\/6J background at postnatal day 9 underwent unilateral common carotid artery ligation, followed by hypoxia. Brain damage was determined by infarct size measurement. Apoptosis was evaluated by measuring the expression of Bax and Bcl\u20102. The levels of inflammatory cytokines and mediators involved in oxidative stress were measured. Nrf2 knockout exacerbated HI injury\u2010induced brain infarct and cell apoptosis in the brain. Nrf2<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed increased inflammatory cytokines and MDA, and reduced activities of antioxidant enzymes including CAT, GSH\u2010Px, and SOD. Nrf2<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed reduced HO\u20101 expression after HI injury compared with wild\u2010type mice. This study supported a protective effect of Nrf2 in neonatal HI brain injury.<\/jats:p>","DOI":"10.1002\/syn.22174","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T16:10:22Z","timestamp":1591200622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neuroprotective role of Nrf2 on hypoxic\u2010ischemic brain injury in neonatal mice"],"prefix":"10.1002","volume":"74","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Emergency Brain Academy District Cangzhou Central Hospital Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Two Obstetrics Cangzhou Central Hospital Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumian","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Emergency Brain Academy District Cangzhou Central Hospital Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7085-3610","authenticated-orcid":false,"given":"Long","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Emergency Brain Academy District Cangzhou Central Hospital Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26071"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.08.190"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.nainr.2011.07.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.26.2.4501"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2015034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-579-8_12"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.365"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2018.1502326"},{"issue":"9","key":"e_1_2_7_11_1","first-page":"453","article-title":"Malondialdehyde (MDA) as a lipid peroxidation marker","volume":"57","author":"Gawel S.","year":"2004","journal-title":"Wiadomosci Lekarskie (Warsaw, Poland: 1960)"},{"issue":"7","key":"e_1_2_7_12_1","first-page":"1532","article-title":"Roles of the Nrf2\/HO\u20101 pathway in the anti\u2010oxidative stress response to ischemia\u2010reperfusion brain injury in rats","volume":"21","author":"Jiang L. J.","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3153"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11624"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.02.036"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211558200"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305204200"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/426769"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.024"},{"issue":"153","key":"e_1_2_7_20_1","article-title":"Critical role of Nrf2 in experimental ischemic stroke","volume":"10","author":"Liu L.","year":"2019","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.04.036"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00088"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.03.019"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.02.031"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20170017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-514-9_4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-805417-8.00003-2"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2741\/4395"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsyn.22174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.22174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/syn.22174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.22174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:23:48Z","timestamp":1693913028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.22174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/syn.22174"],"URL":"https:\/\/doi.org\/10.1002\/syn.22174","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]},"assertion":[{"value":"2020-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22174"}}