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We focused on the role of dopamine transporter (DAT) and inheritance factors in compulsive behavior. Our sample consisted of DAT heterozygous (HET) rats with different genetic inheritance (MAT\u2010HET, born from WT\u2010dams\u00a0\u00d7\u00a0KO\u2010fathers; MIX\u2010HET, born from HET\u2010dams \u00d7 KO\u2010fathers). As controls, we used both wild\u2010type (WT) rats and their socially\u2010isolated (WTi) siblings. We ran the schedule\u2010induced polydipsia (SIP) protocol, to induce compulsive behavior; then the Y\u2010maze and marble\u2010burying tests, to verify its actual development. Only MAT\u2010HET (who inherited the functional DAT allele from the WT mother) is vulnerable to developing compulsive behavior. MAT\u2010HET rats drank increasingly more water during SIP; they showed significant perseverance in the Y\u2010maze test and exhibited compulsive actions in the marble\u2010burying test. Interestingly, compulsive behaviors of MAT\u2010HET rats correlated with expression ex vivo of different genes in different areas. Regarding the prefrontal cortex (PFC), D2R correlated\u00a0with Y\u2010maze \u201cperseverance\u201d in addition to BDNF; considering the amygdala (AMY), both D3R and OXTR correlated with SIP \u201clicks.\u201d Indeed, compulsivity may be linked to D2R and BDNF in PFC, while extreme anxiety in MAT\u2010HET rats may be associated with D3R and OXTR in the AMY. These results confirm some similarities between MAT\u2010HET and DAT\u2010KO subjects, and link the epigenetic context of the DAT gene to the development of compulsive behavior.<\/jats:p>","DOI":"10.1002\/syn.22244","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T23:03:31Z","timestamp":1656630211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dopamine\u2010transporter heterozygous rats carrying maternal wild\u2010type allele are more vulnerable to the development of compulsive behavior"],"prefix":"10.1002","volume":"76","author":[{"given":"Fabiana","family":"Festucci","sequence":"first","affiliation":[{"name":"Center for Behavioural Sciences and Mental Health Istituto Superiore di Sanit\u00e0  Rome Italy"},{"name":"Department of Biotechnological and Applied Clinical Sciences University of L'Aquila  L'Aquila 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Teramo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-4430","authenticated-orcid":false,"given":"Walter","family":"Adriani","sequence":"additional","affiliation":[{"name":"Center for Behavioural Sciences and Mental Health Istituto Superiore di Sanit\u00e0  Rome 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