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Using an animal model of AN, called activity\u2010based anorexia (ABA), we showed earlier that a single intraperitoneal injection of ketamine at a dose of 30 mg\/kg (30mgKET), but not 3 mg\/kg (3mgKET), has a long\u2010lasting effect upon adolescent females of ameliorating anorexia\u2010like symptoms through the following changes: enhanced food consumption and body weight; reduced running and anxiety\u2010like behavior. However, there were also individual differences in the drug's efficacy. We hypothesized that individual differences in ketamine's ameliorative effects involve drebrin A, an F\u2010actin\u2010binding protein known to be required for the activity\u2010dependent trafficking of NMDA receptors (NMDARs). We tested this hypothesis by electron microscopic quantifications of drebrin A immunoreactivity at excitatory synapses of pyramidal neurons (PN) and GABAergic interneurons (GABA\u2010IN) in deep layer 1 of prefrontal cortex (PFC) of these mice. Results reveal that (1) the areal density of excitatory synapses on GABA\u2010IN is greater for the 30mgKET group than the 3mgKET group; (2) the proportion of drebrin A+ excitatory synapses is greater for both PN and GABA\u2010IN of 30mgKET than 3mgKET group. Correlation analyses with behavioral measurements revealed that (3) 30mgKET's protection is associated with reduced levels of drebrin A in the cytoplasm of GABA\u2010IN and higher levels at extrasynaptic membranous sites of PN and GABA\u2010IN; (5) altogether pointing to 30mgKET\u2010induced homeostatic plasticity that engages drebrin A at excitatory synapses of both PN and GABA\u2010IN.<\/jats:p>","DOI":"10.1002\/syn.22253","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T16:34:47Z","timestamp":1663605287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Individual differences in the positive outcome from adolescent ketamine treatment in a female mouse model of anorexia nervosa involve drebrin A at excitatory synapses of the medial prefrontal 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