{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:42:50Z","timestamp":1778272970512,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The brain plays a major role in controlling the desire to eat. This meta\u2010analysis aimed to assess the association between dopamine receptor (DR) availability and dopamine transporter (DAT) availability, measured using positron emission tomography, and obesity. We performed a systematic search of MEDLINE (from inception to November 2020) and EMBASE (from inception to November 2020) for articles published in English using the keywords \u201cdopamine receptor,\u201d \u201cdopamine transporter,\u201d \u201cobesity,\u201d and \u201cneuroimaging.\u201d Body mass index (BMI) and the corresponding binding potential (BP\n                    <jats:sub>ND<\/jats:sub>\n                    ) were extracted from figures in each study using Engauge Digitizer, version 12.1, and plotted for radiopharmaceuticals and regions of interest (ROIs). Five studies involving 119 subjects with DR and five studies including 421 subjects with DAT were eligible for inclusion in this study. In overweight or obese subjects with BMI of 25\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    or higher, DR availability from\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010Racloprie was negatively associated with BMI. However, DR availability from\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010PHNO was positively associated with BMI. DAT ratio was calculated after dividing DAT availabilities of overweight\/obese BMI with mean DAT availabilities of normal BMI. The association between DAT ratio and BMI was not significant regardless of radiopharmaceuticals. In conclusion, dopamine plays a main role in the reward system with regard to obesity. Overweight and obese subjects had negative association between DR availability from\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010Raclopride and BMI. However, the association of DR availability with BMI was dependent on radiopharmaceuticals. DAT availability did not show the significant relationship with BMI regardless of radiopharmaceuticals.\n                  <\/jats:p>","DOI":"10.1002\/syn.22254","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T16:19:00Z","timestamp":1663085940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dopamine receptor and dopamine transporter in obesity: A meta\u2010analysis"],"prefix":"10.1002","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-1894","authenticated-orcid":false,"given":"Kyoungjune","family":"Pak","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Biomedical Research Institute Pusan National University Hospital and School of Medicine, Pusan National University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Won","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-6472","authenticated-orcid":false,"given":"Myung Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology and Biomedical Research Institute Pusan National University Hospital  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Biomedical Research Institute Pusan National University Hospital and School of Medicine, Pusan National University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Biomedical Research Institute Pusan National University Hospital and School of Medicine, Pusan National University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.036"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.149583"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(95)00033-B"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.132340"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.9.928"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.02.017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.03.064"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21680"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.115"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.286"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20392"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2741\/E600"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.102"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0716-8_7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4744\u201014.2015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.153"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3105"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21738"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00846"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2009.08.013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1996.271.3.R491"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2741\/s171"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3745"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2012.59.1.16"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201022814\u20108"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003848\u2010y"},{"key":"e_1_2_7_30_1","unstructured":"World Health Organization. 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