{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:55:00Z","timestamp":1793692500299,"version":"4.5.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we aimed to validate the hypothesis that the interplay between sevoflurane, oxidative stress and ferroptosis is crucial for the pathogenesis of sevoflurane\u2010induced cognitive impairment in aged individuals. The mice with sevoflurane\u2010induced cognitive impairment were used to explore the effects of sevoflurane on oxidative stress, iron homeostasis, and cognitive function in aged mice. Iron content and oxidative stress markers were analyzed in hippocampal tissue homogenates using specific assays. Additionally, the levels of iron death\u2010related markers (Fth1 and Gpx4) were assessed by real\u2010time PCR and Western blotting. Morris Water Maze and novel object recognition (NOR) tests were conducted to evaluate cognitive function. Sevoflurane exposure in aged mice resulted in a significant increase in iron overloading in the hippocampus, followed by a subsequent stabilization. Oxidative stress levels were elevated in the hippocampal tissue of sevoflurane\u2010exposed mice, and a significant correlation was observed between iron death and oxidative stress. Liproxstatin\u20101, a ferroptosis inhibitor, effectively ameliorated the decline in memory and learning abilities induced by sevoflurane anesthesia. Liproxstatin\u20101 treatment reduced iron overload and oxidative stress in the hippocampal tissue of aged mice. The expression of Fth1 and Gpx4, iron death\u2010related markers, was downregulated following Liproxstatin\u20101 intervention. Our findings suggest that sevoflurane anesthesia disrupts iron homeostasis, leading to increased oxidative stress and cognitive impairment in aged mice. These results highlight the potential of targeting iron\u2010mediated processes to mitigate sevoflurane\u2010induced cognitive impairment in the aging population.<\/jats:p>","DOI":"10.1002\/syn.22286","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T05:38:57Z","timestamp":1705383537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Liproxstatin\u20101 alleviates ferroptosis in sevoflurane anesthesia\u2010induced cognitive deficits of aged mice: The role oxidative stress"],"prefix":"10.1002","volume":"78","author":[{"given":"Shunyuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingle","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Quanzhou 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