{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:36:59Z","timestamp":1782941819752,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006564","name":"Bozok \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epileptic seizures are seen as a result of changing excitability balance depending on the deterioration in synaptic plasticity in the brain. Neuroplastin, and its related molecules which are known to play a role in synaptic plasticity, neurotransmitter activities that provide balance of excitability and, different neurological diseases, have not been studied before in epilepsy.<\/jats:p><jats:p>In this study, a total of 34 Sprague\u2013Dawley male and female rats, 2 months old, weighing 250\u2013300\u00a0g were used. The epilepsy model in rats was made via pentylenetetrazole (PTZ). After the completion of the experimental procedure, the brain tissue of the rats were taken and the histopathological changes in the hippocampus and cortex parts and the brain stem were investigated, as well as the immunoreactivity of the proteins related to the immunohistochemical methods.<\/jats:p><jats:p>As a result of the histopathological evaluation, it was determined that neuron degeneration and the number of dilated blood vessels in the hippocampus, frontal cortex, and brain stem were higher in the PTZ status epilepticus (SE) groups than in the control groups. It was observed that neuroplastin and related proteins TNF receptor\u2010associated factor 6 (TRAF6), Gamma amino butyric acid type A receptors [(GABA(A)], and plasma membrane Ca2+\u00a0ATPase (PMCA) protein immunoreactivity levels increased especially in the male hippocampus, and only AMPA receptor subunit type 1 (GluA1) immunoreactivity decreased, unlike other proteins.<\/jats:p><jats:p>We believe this may be caused by a problem in the mechanisms regulating the interaction of neuroplastin and GluA1 and may cause problems in synaptic plasticity in the experimental epilepsy model. It may be useful to elucidate this mechanism and target GluA1 when determining treatment strategies.<\/jats:p>","DOI":"10.1002\/syn.22289","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T15:40:10Z","timestamp":1709566810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gender\u2010related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-3384","authenticated-orcid":false,"given":"Z\u00fcleyha","family":"Do\u011fanyi\u011fit","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Yozgat Bozok University  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Okan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Yozgat Bozok University  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seher","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Anatomy Yozgat Bozok University  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Cihangir","family":"U\u011fuz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biophysics Karamanoglu Mehmetbey University  Karaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enes","family":"Aky\u00fcz","sequence":"additional","affiliation":[{"name":"Faculty of International Medicine, Department of Biophysics University of Health Sciences  Istanbul 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