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The main purpose of this study is to evaluate the anxiolytic activity of LIN and SES co\u2010treatment on Swiss albino mice and analyze its possible mechanism through in silico study. In this sense, the mice were given the gamma\u2010aminobutyric acid type A receptors (GABA<jats:sub>A<\/jats:sub>) agonist diazepam (DZP; 3\u00a0mg\/kg, p.o.) as a positive control. A vehicle (10\u00a0mL\/kg) was served as control. The tested chemicals, single\u2010dose LIN (50\u00a0mg\/kg) and SES (50\u00a0mg\/kg), as well as a combination (LIN\u00a0+\u00a0SES) and (DZP\u00a0+\u00a0LIN\u00a0+\u00a0SES), were administered orally in order to conduct several behavioral tests, including open\u2010field, swings box, hole\u2010crossing, and dark\u2010resident time tests. Further, molecular docking studies of LIN, SES, and DZP were carried out through different software. The results showed that LIN and SES individually have significant anxiolytic\u2010like activity in mice. Further, when LIN was combined with SES and with (SES\u00a0+\u00a0DZP), it exhibited a relatively lower locomotor activity in mice compared to individual treatment groups, indicating a synergistic action. In addition, the molecular docking analysis revealed that LIN and SES have a moderate binding affinity (\u22125.0 and \u22125.1\u00a0kcal\/mol) toward the GABA<jats:sub>A<\/jats:sub> receptor \u03b13 subunit. In conclusion, our findings suggest that LIN and SES exerted synergistic anxiolytic activity on <jats:italic>Swiss<\/jats:italic> albino mice, possibly through the GABAergic interaction pathways.<\/jats:p>","DOI":"10.1002\/syn.70003","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T15:20:32Z","timestamp":1735312832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synergistic Anxiolytic Effects of Linalool and Sesamol Co\u2010Treatment on Swiss Albino Mice: A Potential GABAergic Intervention"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-3820","authenticated-orcid":false,"given":"Muhammad Torequl","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd.  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