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Our prior work revealed sex differences in the distribution of CRFR1 within CA3 pyramidal cells and hilar interneurons in rats that could differentially affect associative learning processes in females and males, especially in response to chronic immobilization stress (CIS). Here, we examine the effect of oxycodone (Oxy) conditioned place preference (CPP) in unstressed and CIS adult female and male rats on the subcellular distribution of CRFR1 in CA3 pyramidal cells and dentate gyrus (DG) hilar interneurons using immuno\u2010electron microscopy. After Oxy CPP, males compared to females had greater plasmalemmal\u2010associated CRFR1 in CA3 pyramidal cell and DG interneuron dendrites, consistent with a greater binding capacity for corticotropin\u2010releasing factor (CRF) in males. CIS alone resulted in increases in corticotropin\u2010releasing hormone receptor 1 (\n                    <jats:italic>Crhr1<\/jats:italic>\n                    ) mRNA in the pyramidal cell layer and stratum oriens of CA3 in males. Following CIS and Oxy CPP behavior, only females acquired CPP. Oxy CIS females compared to Oxy CIS males had more total CRFR1 in DG interneuron dendrites. Moreover, CRFR1 trafficked from the cytoplasm toward the plasmalemma in DG interneuron dendrites in CIS Oxy females, indicating a potential greater binding capacity for CIS Oxy females in this neuronal population. These findings along with prior studies suggest that changes in CRFR1 and opioid receptor trafficking in CIS females contribute to mechanisms that are associated with the development of Oxy CPP in CIS females, but not males.\n                  <\/jats:p>","DOI":"10.1002\/syn.70057","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:02:43Z","timestamp":1787821363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex and Chronic Stress Alter the Distribution of Corticotropin\u2010Releasing Factor Receptor in Rat Hippocampus Following Oxycodone Conditioned Place Preference"],"prefix":"10.1002","volume":"80","author":[{"given":"Dana N.","family":"Silberstein","sequence":"first","affiliation":[{"name":"Feil Family Brain and Mind Research Institute Weill Cornell Medicine  New York City New York 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