{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:09:23Z","timestamp":1790240963437,"version":"4.1.0"},"reference-count":170,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Synapse"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Epilepsy is a complex neurological disorder characterized by recurrent seizures resulting from an imbalance between excitatory and inhibitory neurotransmission. \u03b3\u2010Aminobutyric acid type A receptors (GABA\n                    <jats:sub>A<\/jats:sub>\n                    Rs), the principal mediators of fast inhibitory synaptic transmission, are essential for maintaining neuronal stability. Their function depends on tightly regulated trafficking processes, including subunit assembly in the endoplasmic reticulum, transport through the Golgi apparatus, membrane insertion, synaptic targeting, stabilization, and recycling. Disruptions in these processes, caused by genetic mutations, aberrant posttranslational modifications, or seizure\u2010induced neuronal activity, impair receptor surface expression and localization, reducing inhibitory signaling and promoting network hyperexcitability. Evidence from human and animal studies indicates that altered GABA\n                    <jats:sub>A<\/jats:sub>\n                    R trafficking contributes to epileptogenesis and pharmacoresistance, particularly during severe conditions such as status epilepticus. Understanding the molecular mechanisms regulating GABA\n                    <jats:sub>A<\/jats:sub>\n                    R trafficking provides insights into epilepsy pathophysiology and highlights potential therapeutic strategies aimed at restoring inhibitory balance. By linking these trafficking mechanisms to synaptic structure and ion channel function, this review situates GABA\n                    <jats:sub>A<\/jats:sub>\n                    R biogenesis within the broader framework of synaptic organization relevant to epilepsy and other neurological disorders.\n                  <\/jats:p>","DOI":"10.1002\/syn.70060","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:57:23Z","timestamp":1789369043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GABA\n                    <sub>A<\/sub>\n                    Receptor Trafficking Disruption in Epilepsy: From Assembly to Synaptic Dysfunction"],"prefix":"10.1002","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5847-3001","authenticated-orcid":false,"given":"Tahere","family":"Mohammadpour","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Biology, Faculty of Basic Sciences University of Maragheh  Maragheh Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-5151","authenticated-orcid":false,"given":"Reza","family":"Mohammadzadeh","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, Faculty of Basic Sciences University of Maragheh  Maragheh Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00132"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4011\u201004.2005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.05.016"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106633"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.04.023"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2011.03247.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy019"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200438200"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901\u2010908"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.068478"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801708200"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2009.06863.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1044\u20107431(02)00017\u20109"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409095200"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.012"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199746545.003.0044"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010022\u201000664\u20103"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0510\u201022.2022"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09582"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2004.02481.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.08.003"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/EMM.2015.5"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0270\u201010.2010"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng885"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210\u2010200115050\u201000001"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.11.005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.09.020"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.705004"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh146"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00515"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.09.014"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2007.01301.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101718719"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4214\u201006.2006"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20928"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1625"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010015\u20109164\u20108"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2913\u201005.2006"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2022.07.007"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.015"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903590111"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608910200"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2015.11.002"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700163104"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14152"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0521\u201024.2024"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43141\u2010021\u201000224\u20100"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4751\u201007.2008"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00113"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12063"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0900\u201005.2005"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3426\u201007.2008"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.07.006"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525726113"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00479"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2748\u201019.2020"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.10.075"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7872"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.218883"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.09.015"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301420200"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.10.007"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005481\u20101"},{"key":"e_1_2_12_66_1","volume-title":"Progress in Brain Research","author":"Hirose S.","year":"2014"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.04.015"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2370"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114775"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00313"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.603068"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101718722"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2010.03.002"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858416645087"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201438840"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.5.1004"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4024"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806484200"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)00225\u20102"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1037\u201004.2004"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10309\u2010023\u201000622\u2010z"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.732768"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506653102"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707920105"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:26:2\u20103:251"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401860101"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1042\/BC20060120"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100066\u20109"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.2.445"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15330"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3355\u201004.2004"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010013\u20108558\u20108"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004596\u20104"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17746"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600995"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00265"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22536"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.120.019539"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.03.024"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.303412"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4433\u201007.2007"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27443"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/223"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00077"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13742"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13293"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/377344a0"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000589107"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2001\u201011.2011"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.012"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2014.11.008"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.216499"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4944\u201004.2005"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/25999"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18\u201005\u201001693.1998"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098458"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.108.00505"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013185"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2005.04448.x"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601819"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0514\u201016.2016"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4921"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199746545.003.0056"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/embr.201438749"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa028"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17470"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105296"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.01.012"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1341472"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5265\u201003.2004"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802077200"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004517\u20103"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.72"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.072"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1622\u201011.2011"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2010.04.004"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab239"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1177\/15357597231204594"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz085"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708440104"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.04.020"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524013113"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4346\u201007.2008"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32596\u20100"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22235"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5332\u201011.2012"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.05.013"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2012.00023"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417989112"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.007"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.178517"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0024\u20103205(02)02275\u20100"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010093010\u2010153308"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1078\/0171\u20109335\u201000410"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.10.006"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2010"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.09.006"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/16264"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578\u2010022\u201000783\u2010w"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.5.2099"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104754"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010023\u201001120\u20106"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010022\u201001334\u20100"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.015"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.023"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020624\u2010z"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.008"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1063\u201012.2012"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12629"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.444372"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738241273437"}],"container-title":["Synapse"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.70060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/syn.70060","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/syn.70060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:45:40Z","timestamp":1790239540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/syn.70060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":170,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/syn.70060"],"URL":"https:\/\/doi.org\/10.1002\/syn.70060","archive":["Portico"],"relation":{},"ISSN":["0887-4476","1098-2396"],"issn-type":[{"value":"0887-4476","type":"print"},{"value":"1098-2396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70060"}}