{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T12:43:07Z","timestamp":1698064987203},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":6129,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synapse"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Responses to substance P (SP) and to hypogastric nerve stimulation were recorded from voltage\u2010clamped guinea pig inferior mesenteric ganglion (IMG) neurons, and compared with those to muscarine. Muscarine produced a voltage\u2010dependent inward current accompanied by a reduced input conductance and inhibition of I<jats:sub>M<\/jats:sub> a time\u2010 and voltage\u2010dependent K<jats:sup>+<\/jats:sup>\u2010current (Brown and Adams: <jats:italic>Nature<\/jats:italic> 283:673\u2013676, 1980). SP also produced an inward current, accompanied by a fall in input conductance (20 out of 31 cells) or a rise in input conductance (7 out of 31 cells). The fall in input conductance was not accompanied by an inhibition of M\u2010current (unlike frog ganglia: Adams et al.: <jats:italic>British Journal of Pharmacology<\/jats:italic> 79:330\u2013333, 1983) or an inhibition of the inward rectifier current (unlike globus pallidus neurons: Stanfield et al.: <jats:italic>Nature<\/jats:italic> 315:498\u2013501, 1985). Repetitive hypogastric nerve stimulation (10\u201320 Hz, 2\u201310 s) produced a slow inward postsynaptic current lasting 1\u20133 min, with decreases or increases of input conductance matching those produced by SP. The postsynaptic current did not show a consistent or reproducible change in amplitude on varying the holding potential between \u201090 and \u201025 mV. It is concluded that SP and hypogastric stimulation produce complex and variable changes in ionic conductance in IMG neurons.<\/jats:p>","DOI":"10.1002\/syn.890020411","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:30:03Z","timestamp":1104593403000},"page":"432-441","source":"Crossref","is-referenced-by-count":5,"title":["Substance P\u2010mediated membrane currents in voltage\u2010clamped guinea pig inferior mesenteric ganglion cells"],"prefix":"10.1002","volume":"2","author":[{"given":"William H.","family":"Griffith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith M.","family":"Hills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1980.tb14547.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014412"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014357"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014411"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb11004.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90240-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/283673a0"},{"key":"e_1_2_1_9_1","first-page":"157","article-title":"Some ionic mechanisms of slow peptidergic neuronal excitation","volume":"4","author":"Brown D. 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